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Virus-Cell Interactions

Genetic Mapping of the Cloned Subgroup A Avian Sarcoma and Leukosis Virus Receptor Gene to the TVALocus

Paul Bates, Lijun Rong, Harold E. Varmus, John A. T. Young, Lyman B. Crittenden
Paul Bates
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076;
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Lijun Rong
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076;
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Harold E. Varmus
National Institutes of Health, Bethesda, Maryland 20892;
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John A. T. Young
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115; and
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Lyman B. Crittenden
USDA Avian Disease and Oncology Laboratory and Department of Microbiology, Michigan State University, East Lansing, Michigan 48824
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DOI: 10.1128/JVI.72.3.2505-2508.1998
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ABSTRACT

A chicken gene conferring susceptibility to subgroup A avian sarcoma and leukosis viruses (ASLV-A) was recently identified by a gene transfer strategy. Classical genetic approaches had previously identified a locus, TVA, that controls susceptibility to ASLV-A. Using restriction fragment length polymorphism (RFLP) mapping in inbred susceptible (TVA*S) and resistant (TVA*R) chicken lines, we demonstrate that in 93 F2 progeny an RFLP for the cloned receptor gene segregates with TVA. From these analyses we calculate that the cloned receptor gene lies within 5 centimorgans of TVA, making it highly probable that the cloned gene is the previously identified locusTVA. The polymorphism that distinguishes the two alleles ofTVA in these inbred lines affects the encoded amino acid sequence of the region of Tva that encompasses the viral binding domain. However, analysis of the genomic sequence encoding this region of Tva in randomly bred chickens suggests that the altered virus binding domain is not the basis for genetic resistance in the chicken lines analyzed.

  • Copyright © 1998 American Society for Microbiology
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Genetic Mapping of the Cloned Subgroup A Avian Sarcoma and Leukosis Virus Receptor Gene to the TVALocus
Paul Bates, Lijun Rong, Harold E. Varmus, John A. T. Young, Lyman B. Crittenden
Journal of Virology Mar 1998, 72 (3) 2505-2508; DOI: 10.1128/JVI.72.3.2505-2508.1998

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Genetic Mapping of the Cloned Subgroup A Avian Sarcoma and Leukosis Virus Receptor Gene to the TVALocus
Paul Bates, Lijun Rong, Harold E. Varmus, John A. T. Young, Lyman B. Crittenden
Journal of Virology Mar 1998, 72 (3) 2505-2508; DOI: 10.1128/JVI.72.3.2505-2508.1998
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KEYWORDS

avian leukosis virus
Avian Sarcoma Viruses
Chromosome Mapping
Receptors, Virus

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