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Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.

Two distinct oncornaviruses harbor an intracytoplasmic tyrosine-based basolateral targeting signal in their viral envelope glycoprotein.

R Lodge, L Delamarre, J P Lalonde, J Alvarado, D A Sanders, M C Dokhélar, E A Cohen, G Lemay
R Lodge
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L Delamarre
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J P Lalonde
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J Alvarado
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D A Sanders
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M C Dokhélar
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E A Cohen
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G Lemay
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ABSTRACT

It has been clearly established that the budding of the human immunodeficiency virus (HIV-1), a lentivirus, occurs specifically through the basolateral membrane in polarized epithelial cells. More recently, the signal was assigned to a tyrosine-based motif located in the intracytoplasmic domain of the envelope glycoprotein, as previously observed on various other viral and cellular basolateral proteins. In the present study, expression of human T-cell leukemia virus type 1 (HTLV-1) or Moloney murine leukemia virus envelope glycoproteins was used for trans-complementation of an envelope-negative HIV-1. This demonstrated the potential of oncornaviral retrovirus envelope glycoproteins to confer polarized basolateral budding in epithelial Madin-Darby canine kidney cells (MDCK cells). Site-directed mutagenesis confirmed the importance of a common motif encompassing at least one crucial membrane-proximal intracytoplasmic tyrosine residue. The conservation of a similar basolateral maturation signal in different retroviruses further supports its importance in the biology of this group of viruses.

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Two distinct oncornaviruses harbor an intracytoplasmic tyrosine-based basolateral targeting signal in their viral envelope glycoprotein.
R Lodge, L Delamarre, J P Lalonde, J Alvarado, D A Sanders, M C Dokhélar, E A Cohen, G Lemay
Journal of Virology Jul 1997, 71 (7) 5696-5702; DOI:

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Two distinct oncornaviruses harbor an intracytoplasmic tyrosine-based basolateral targeting signal in their viral envelope glycoprotein.
R Lodge, L Delamarre, J P Lalonde, J Alvarado, D A Sanders, M C Dokhélar, E A Cohen, G Lemay
Journal of Virology Jul 1997, 71 (7) 5696-5702; DOI:
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