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Journal Article | Research Support, U.S. Gov't, Non-P.H.S. | Research Support, U.S. Gov't, P.H.S.

Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development.

H Cao, P Kanki, J L Sankalé, A Dieng-Sarr, G P Mazzara, S A Kalams, B Korber, S Mboup, B D Walker
H Cao
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P Kanki
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J L Sankalé
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A Dieng-Sarr
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G P Mazzara
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S A Kalams
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B Korber
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S Mboup
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B D Walker
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ABSTRACT

Despite recent advances in antiviral therapy for human immunodeficiency virus (HIV) infection, successful global intervention will require an effective vaccine. Expanding evidence suggests that cytotoxic T-lymphocyte (CTL) responses will be an important component of such a vaccine. The varying geographic distribution of HIV type 1 (HIV-1) clades, with the relative absence of clade B HIV-1 outside the developed world, is considered a major obstacle to the development of a single efficacious vaccine. An understanding of cross-reactive CTL responses between different HIV-1 clades is crucial in the design of a vaccine which will be broadly immunogenic. In this study, we examined the ability of HIV-1 Gag-, reverse transcriptase-, and Env-specific CTL clones isolated from individuals infected in the United States to recognize non-B clade viral sequences and found that all were cross-reactive with the majority of non-B clade viral sequences tested. We next studied HIV-1-specific CTL responses in African individuals infected with clade A, C, or G virus and evaluated cross-recognition of clade B virus. Of 14 persons evaluated, all demonstrated cross-reactivity with the U.S. clade B viral constructs. We conclude that significant CTL cross-reactivity exists between clade B and non-B epitopes, suggesting that CTL cross-recognition among HIV-1 clades is more widespread than anticipated and that a vaccine based on a single clade may be broadly applicable.

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Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development.
H Cao, P Kanki, J L Sankalé, A Dieng-Sarr, G P Mazzara, S A Kalams, B Korber, S Mboup, B D Walker
Journal of Virology Nov 1997, 71 (11) 8615-8623; DOI:

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Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development.
H Cao, P Kanki, J L Sankalé, A Dieng-Sarr, G P Mazzara, S A Kalams, B Korber, S Mboup, B D Walker
Journal of Virology Nov 1997, 71 (11) 8615-8623; DOI:
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