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Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.

Influenza virus neuraminidase activates latent transforming growth factor beta.

S Schultz-Cherry, V S Hinshaw
S Schultz-Cherry
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V S Hinshaw
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DOI: 
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ABSTRACT

Transforming growth factor beta (TGF-beta) is a family of proteins secreted by virtually all cells in a biologically inactive form. TGF-beta levels increase during many pathophysiological situations, including viral infection. The mechanism for increased TGF-beta activity during viral infection is not understood. We observed an increase in active TGF-beta levels within 1 day in mice infected with influenza virus. Further studies showed that the neuraminidase glycoprotein of influenza A and B viruses directly activates latent TGF-beta in vitro. There are sufficient levels of TGF-beta activated by virus to induce apoptosis in cells. In addition, influenza virus-induced apoptosis is partially inhibited by TGF-beta-specific antibodies. These novel findings suggest a potential role for activation of TGF-beta during the host response to influenza virus infection, specifically apoptosis. This is the first report showing direct activation of latent TGF-beta by a viral protein.

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Influenza virus neuraminidase activates latent transforming growth factor beta.
S Schultz-Cherry, V S Hinshaw
Journal of Virology Dec 1996, 70 (12) 8624-8629; DOI:

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Influenza virus neuraminidase activates latent transforming growth factor beta.
S Schultz-Cherry, V S Hinshaw
Journal of Virology Dec 1996, 70 (12) 8624-8629; DOI:
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