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Journal Article | Research Support, Non-U.S. Gov't

Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation.

A P Dackiw, K Zakrzewski, A B Nathens, P Y Cheung, R Fingerote, G A Levy, O D Rotstein
A P Dackiw
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K Zakrzewski
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A B Nathens
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P Y Cheung
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R Fingerote
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G A Levy
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O D Rotstein
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ABSTRACT

The induction of a unique macrophage procoagulant molecule by murine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in phosphotyrosine accumulation. Tyrosine kinase inhibition precluded this increase and abrogated expression of the virus-induced procoagulant mouse fibrinogen-like protein (musfiblp) gene. These findings suggest that manipulation of this signalling pathway in vivo might represent a novel approach to treating this disease.

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Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation.
A P Dackiw, K Zakrzewski, A B Nathens, P Y Cheung, R Fingerote, G A Levy, O D Rotstein
Journal of Virology Sep 1995, 69 (9) 5824-5828; DOI:

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Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation.
A P Dackiw, K Zakrzewski, A B Nathens, P Y Cheung, R Fingerote, G A Levy, O D Rotstein
Journal of Virology Sep 1995, 69 (9) 5824-5828; DOI:
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