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Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.

Binding motifs predict major histocompatibility complex class II-restricted epitopes in the Sendai virus M protein.

G A Cole, T Tao, T L Hogg, K W Ryan, D L Woodland
G A Cole
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T Tao
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T L Hogg
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K W Ryan
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D L Woodland
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ABSTRACT

Major histocompatibility complex (MHC) class I ligand motifs have been defined for a number of class I molecules and have been successfully used to identify class I-restricted cytotoxic T-cell epitopes. In contrast, the relative degeneracy of sequence motifs in naturally processed MHC class II ligands has suggested that they may be of more limited use. Here, we use a predicted I-Ab ligand motif to identify antigenic peptides in the Sendai virus Enders strain matrix (M) protein. The entire coding sequence of the M protein was derived, and seven peptide sequences that contained the predicted I-Ab motif were identified. Analysis of I-Ab-restricted M-specific T-cell hybridomas for reactivity to these synthetic peptides identified two distinct epitopes. These data demonstrate that MHC class II motifs can be valuable in predicting T-cell epitopes.

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Binding motifs predict major histocompatibility complex class II-restricted epitopes in the Sendai virus M protein.
G A Cole, T Tao, T L Hogg, K W Ryan, D L Woodland
Journal of Virology Dec 1995, 69 (12) 8057-8060; DOI:

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Binding motifs predict major histocompatibility complex class II-restricted epitopes in the Sendai virus M protein.
G A Cole, T Tao, T L Hogg, K W Ryan, D L Woodland
Journal of Virology Dec 1995, 69 (12) 8057-8060; DOI:
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