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Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.

Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri.

J U Jung, S M Lang, T Jun, T M Roberts, A Veillette, R C Desrosiers
J U Jung
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S M Lang
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T Jun
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T M Roberts
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A Veillette
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R C Desrosiers
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ABSTRACT

A protein, called tip, of herpesvirus saimiri associates with Lck in transformed T cells. To investigate the effects of complex formation on cellular signal transduction, we constructed human Jurkat-T-cell lines expressing tip. The expression of tip in Jurkat-T cells dramatically suppressed cellular tyrosine phosphorylation and surface expression of lymphocyte antigens. The expression of tip also blocked the induction of tyrosine phosphorylation by anti-CD3 stimulation. The expression of tip in fibroblast cells suppressed the transforming activity of oncogenic F505 Lck. Binding assays showed that the SH3 domain of Lck is sufficient to form a stable complex with tip in vitro. These results demonstrate that tip acts at an early stage of the T-cell signal transduction cascade by associating with Lck and downregulating Lck-mediated activation. Inhibition of Lck-mediated signal transduction by tip in T cells appears to be analogous to the inhibition of Lyn/Syk-mediated signal transduction in B cells by LMP2A of the B-cell-tropic Epstein-Barr virus.

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Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri.
J U Jung, S M Lang, T Jun, T M Roberts, A Veillette, R C Desrosiers
Journal of Virology Dec 1995, 69 (12) 7814-7822; DOI:

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Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri.
J U Jung, S M Lang, T Jun, T M Roberts, A Veillette, R C Desrosiers
Journal of Virology Dec 1995, 69 (12) 7814-7822; DOI:
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