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Research Article

Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production.

D M Margolis, M Somasundaran, M R Green
D M Margolis
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M Somasundaran
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M R Green
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ABSTRACT

The transcriptional activity of human immunodeficiency virus type 1 (HIV-1) is affected by many cellular factors. Homologies near the HIV-1 initiator region to the DNA-binding sequences of YY1, a multifunctional transcription factor known to regulate diverse viral and cellular promoters, suggested that YY1 might regulate HIV-1. Antibody to YY1 blocked the formation of complexes by HeLa cell nuclear extract and a DNA oligonucleotide encoding the HIV-1 initiator region. HIV-1 long terminal repeat (LTR) expression, as measured the expression of a transfected LTR-CAT reporter gene, was repressed more than 12-fold by the cotransfection of a YY1 expression vector. HIV-1 production by both COS-1 and CEM cells after transfection of an infectious molecular HIV-1 clone was repressed 7- to 20-fold by cotransfection of a YY1 expression vector. HIV-1 production was also decreased threefold in a CD4-positive lymphocyte cell line chronically infected with HIV-1 (8E5) after transfection of YY1. In situ hybridization studies confirmed that YY1 reduced HIV-1 RNA expression. YY1 may play an important role in the regulation of HIV-1 LTR expression in vivo and virus production by infected cells.

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Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production.
D M Margolis, M Somasundaran, M R Green
Journal of Virology Feb 1994, 68 (2) 905-910; DOI:

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Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production.
D M Margolis, M Somasundaran, M R Green
Journal of Virology Feb 1994, 68 (2) 905-910; DOI:
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