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Research Article

Identification and characterization of an extended Tax protein in human T-cell lymphotropic virus type II subtype b isolates.

D Pardi, J E Kaplan, J E Coligan, T M Folks, R B Lal
D Pardi
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J E Kaplan
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J E Coligan
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T M Folks
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R B Lal
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ABSTRACT

The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-IIG12) was found to encode an extended Tax protein when compared with that of HTLV-IIMoT. In vitro transcription-translation of the HTLV-IIG12 tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HTLV-II-infected individuals. Limited sequence analysis demonstrated that isolates with an extended Tax protein were all HTLV-II subtype b (HTLV-IIb). Therefore, the extended Tax protein appears to be a unique characteristic of most HTLV-IIb isolates and may be useful in designing immunoassays to distinguish between HTLV-IIa and HTLV-IIb.

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Identification and characterization of an extended Tax protein in human T-cell lymphotropic virus type II subtype b isolates.
D Pardi, J E Kaplan, J E Coligan, T M Folks, R B Lal
Journal of Virology Dec 1993, 67 (12) 7663-7667; DOI:

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Identification and characterization of an extended Tax protein in human T-cell lymphotropic virus type II subtype b isolates.
D Pardi, J E Kaplan, J E Coligan, T M Folks, R B Lal
Journal of Virology Dec 1993, 67 (12) 7663-7667; DOI:
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