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ANIMAL VIRUSES

Formation of Cellular Deoxyribonucleic Acid During Productive Polyoma Virus Infection

William P. Cheevers, Philip E. Branton, Rose Sheinin
William P. Cheevers
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Philip E. Branton
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Rose Sheinin
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ABSTRACT

It was previously shown that the majority of deoxyribonucleic acid (DNA) made in growing mouse embryo cells productively infected at low multiplicity with polyoma virus is cellular in nature and that some of this cell DNA contains discontinuities in the newly synthesized strand. Evidence obtained indicates the following. (i) Induction of cell DNA synthesis precedes the onset of detectable viral DNA replication by approximately 3 hr. (ii) Double-stranded cell DNA molecules, discontinuous in the newly synthesized strands, arise by direct synthesis (rather than by degradation of a high-molecular-weight precursor) only in the cell DNA replicated after initiation of viral DNA synthesis. (iii) This DNA component is continuously formed throughout the “late” stage of infection and is continuously converted into apparently normal cell DNA of high molecular weight without prior degradation to acid-soluble components.

FOOTNOTES

  • ↵1 Postdoctoral Fellow of the Medical Research Council of Canada. Present address: Cancer Research Laboratory, University of Western Ontario, London, Ontario, Canada.

  • ↵2 Predoctoral Fellow of the National Cancer Institute of Canada.

  • Copyright © 1970 American Society for Microbiology
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Formation of Cellular Deoxyribonucleic Acid During Productive Polyoma Virus Infection
William P. Cheevers, Philip E. Branton, Rose Sheinin
Journal of Virology Nov 1970, 6 (5) 573-582; DOI:

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Formation of Cellular Deoxyribonucleic Acid During Productive Polyoma Virus Infection
William P. Cheevers, Philip E. Branton, Rose Sheinin
Journal of Virology Nov 1970, 6 (5) 573-582; DOI:
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