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BACTERIAL VIRUSES

Early Biochemical Events Occurring After Infection of Bacillus cereus 569-SP1 with Bacteriophage GSW

Hevion Ben-Horin, M. Antoinette Walz, Arthur K. Saz
Hevion Ben-Horin
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M. Antoinette Walz
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Arthur K. Saz
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ABSTRACT

After infection of Bacillus cereus 569-SP1 with the 5-hydroxymethyluracil-containing phage GSW, new dTTPase, dUTPase, and dUMP-hydroxymethylase activities appear. No significant changes in activities of other pyrimidine ribonucleoside or 2′-deoxyribonucleoside triphosphate nucleotidohydrolases were detected. dUTP and dUMP inhibit the dTTPase activity, whereas dTTP failed to inhibit dUTPase activity. The Km value for the substrate dUTP is 10−4 M and for dTTP is 4.85 × 10−4 M. Thymidylate synthetase activity is inhibited only when cells are infected during the late lag or very early log phases of growth; when cells are infected with phage during mid-log, thymidylate synthetase activity is unaffected. The data support the suggestion that, although phage GSW may inhibit an otherwise expected increase in activity of thymidylate synthetase, it fails to affect the already existing activity. The data presented do not allow discrimination as to whether the phage specifies inhibition of de novo synthesis of thymidylate synthetase or the increase in activity of already existing but not fully expressed enzyme.

FOOTNOTES

  • ↵1 Present address: National Cancer Institure and National Institute of Dental Research, Bethesda, Md. 20014, respectively.

  • Copyright © 1974 American Society for Microbiology
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Early Biochemical Events Occurring After Infection of Bacillus cereus 569-SP1 with Bacteriophage GSW
Hevion Ben-Horin, M. Antoinette Walz, Arthur K. Saz
Journal of Virology Apr 1974, 13 (4) 828-836; DOI:

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Early Biochemical Events Occurring After Infection of Bacillus cereus 569-SP1 with Bacteriophage GSW
Hevion Ben-Horin, M. Antoinette Walz, Arthur K. Saz
Journal of Virology Apr 1974, 13 (4) 828-836; DOI:
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