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Articles of Significant Interest in This Issue

Gem

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Gem
Emerging Proviral Roles of Caspases during Lytic Replication of Gammaherpesviruses
Tate Tabtieng, Marta M. Gaglia

Structure and Assembly

Structure and Assembly | Spotlight
The RNA-Binding Protein of a Double-Stranded RNA Virus Acts like a Scaffold Protein
Carlos P. Mata, Johann Mertens, Juan Fontana, Daniel Luque, Carolina Allende-Ballestero, David Reguera, Benes L. Trus, Alasdair C. Steven, José L. Carrascosa, José R. Castón

Genome Replication and Regulation of Viral Gene Expression

Genome Replication and Regulation of Viral Gene Expression
Mutant Cellular AP-1 Proteins Promote Expression of a Subset of Epstein-Barr Virus Late Genes in the Absence of Lytic Viral DNA Replication
Danielle E. Lyons, Kuan-Ping Yu, Jason A. Vander Heiden, Lee Heston, Dirk P. Dittmer, Ayman El-Guindy, George Miller

Genetic Diversity and Evolution

Genetic Diversity and Evolution
Cell-Derived Viral Genes Evolve under Stronger Purifying Selection in Rhadinoviruses
Amr Aswad, Aris Katzourakis
Genetic Diversity and Evolution
Genetic Evidence Supports Sporadic and Independent Introductions of Subtype H5 Low-Pathogenic Avian Influenza A Viruses from Wild Birds to Domestic Poultry in North America
Lei Li, Andrew S. Bowman, Thomas J. DeLiberto, Mary L. Killian, Scott Krauss, Jacqueline M. Nolting, Mia Kim Torchetti, Andrew M. Ramey, Andrew B. Reeves, David E. Stallknecht, Richard J. Webby, Xiu-Feng Wan

Virus-Cell Interactions

Virus-Cell Interactions
Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells
Cindy Buffone, Alicia Martinez-Lopez, Thomas Fricke, Silvana Opp, Marco Severgnini, Ingrid Cifola, Luca Petiti, Stella Frabetti, Katarzyna Skorupka, Kaneil K. Zadrozny, Barbie K. Ganser-Pornillos, Owen Pornillos, Francesca Di Nunzio, Felipe Diaz-Griffero
Virus-Cell Interactions
Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells
Shutoku Matsuyama, Kazuya Shirato, Miyuki Kawase, Yutaka Terada, Kengo Kawachi, Shuetsu Fukushi, Wataru Kamitani
Open Access

Virus-Cell Interactions | Spotlight
Herpes Simplex Virus 1 Infection Promotes the Growth of a Subpopulation of Tumor Cells in Three-Dimensional Uveal Melanoma Cultures
Tibor Valyi-Nagy, Brian Fredericks, Aditya Ravindra, James Hopkins, Deepak Shukla, Klara Valyi-Nagy
Virus-Cell Interactions
Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype
Yuchen Xia, Xiaoming Cheng, Yao Li, Kristin Valdez, Weiping Chen, T. Jake Liang
Virus-Cell Interactions
Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway
John B. Ruedas, Catherine E. Arnold, Gustavo Palacios, John H. Connor
Virus-Cell Interactions
Sendai Virus V Protein Inhibits the Secretion of Interleukin-1β by Preventing NLRP3 Inflammasome Assembly
Takayuki Komatsu, Yukie Tanaka, Yoshinori Kitagawa, Naoki Koide, Yoshikazu Naiki, Naoko Morita, Bin Gotoh, Takashi Yokochi
Virus-Cell Interactions
Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells
Ross W. Walton, Michael C. Brown, Matthew T. Sacco, Matthias Gromeier
Open Access

Virus-Cell Interactions
The S2 Subunit of Infectious Bronchitis Virus Beaudette Is a Determinant of Cellular Tropism
Erica Bickerton, Helena J. Maier, Phoebe Stevenson-Leggett, Maria Armesto, Paul Britton
Open Access

Virus-Cell Interactions
Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus
Kristina Nyström, Paulina H. Wanrooij, Jesper Waldenström, Ludmila Adamek, Sofia Brunet, Joanna Said, Staffan Nilsson, Megan Wind-Rotolo, Kristoffer Hellstrand, Helene Norder, Ka-Wei Tang, Martin Lagging
Virus-Cell Interactions
Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity
Hui Yuan, Jia You, Hongjuan You, Chunfu Zheng
Virus-Cell Interactions
Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans
Aitor Nogales, Luis Martinez-Sobrido, Kevin Chiem, David J. Topham, Marta L. DeDiego
Virus-Cell Interactions
Strategy of Human Cytomegalovirus To Escape Interferon Beta-Induced APOBEC3G Editing Activity
Sara Pautasso, Ganna Galitska, Valentina Dell'Oste, Matteo Biolatti, Rachele Cagliani, Diego Forni, Marco De Andrea, Marisa Gariglio, Manuela Sironi, Santo Landolfo

Cellular Response to Infection

Cellular Response to Infection
MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2
Ashish Kumar, Akhilesh Kumar, Harshad Ingle, Sushil Kumar, Richa Mishra, Mahendra Kumar Verma, Debasis Biswas, Nachimuthu Senthil Kumar, Anamika Mishra, Ashwin Ashok Raut, Akinori Takaoka, Himanshu Kumar
Cellular Response to Infection
Expression of the Vaccinia Virus Antiapoptotic F1 Protein Is Blocked by Protein Kinase R in the Absence of the Viral E3 Protein
Ninad Mehta, Emeka K. Enwere, Theodore Dos Santos, Holly A. Saffran, Bart Hazes, David Evans, Michele Barry, James R. Smiley

Transformation and Oncogenesis

Open Access

Transformation and Oncogenesis | Spotlight
Enhancer Control of MicroRNA miR-155 Expression in Epstein-Barr Virus-Infected B Cells
C. David Wood, Thomas Carvell, Andrea Gunnell, Opeoluwa O. Ojeniyi, Cameron Osborne, Michelle J. West

Prions

Open Access

Prions
Oral Prion Neuroinvasion Occurs Independently of PrP^C Expression in the Gut Epithelium
Alison Marshall, Barry M. Bradford, Alan R. Clarke, Jean C. Manson, Neil A. Mabbott

Vaccines and Antiviral Agents

Vaccines and Antiviral Agents
Analysis of Complement-Mediated Lysis of Simian Immunodeficiency Virus (SIV) and SIV-Infected Cells Reveals Sex Differences in Vaccine-Induced Immune Responses in Rhesus Macaques
Leia K. Miller-Novak, Jishnu Das, Thomas A. Musich, Thorsten Demberg, Joshua A. Weiner, David J. Venzon, Venkatramanan Mohanram, Diego A. Vargas-Inchaustegui, Iskra Tuero, Margaret E. Ackerman, Galit Alter, Marjorie Robert-Guroff
Vaccines and Antiviral Agents
Multiantigenic Modified Vaccinia Virus Ankara Vaccine Vectors To Elicit Potent Humoral and Cellular Immune Reponses against Human Cytomegalovirus in Mice
Flavia Chiuppesi, Jenny Nguyen, Soojin Park, Heidi Contreras, Mindy Kha, Zhuo Meng, Teodora Kaltcheva, Angelina Iniguez, Joy Martinez, Corinna La Rosa, Felix Wussow, Don J. Diamond
Vaccines and Antiviral Agents | Spotlight
SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement
Nirmin Alsahafi, Sai Priya Anand, Luis Castillo-Menendez, Myriam Maude Verly, Halima Medjahed, Jérémie Prévost, Alon Herschhorn, Jonathan Richard, Arne Schön, Bruno Melillo, Ernesto Freire, Amos B. Smith, Joseph Sodroski, Andrés Finzi

Pathogenesis and Immunity

Pathogenesis and Immunity
Characterization of the Plasmacytoid Dendritic Cell Response to Transmitted/Founder and Nontransmitted Variants of HIV-1
Jordan Ari Schwartz, Hongliang Zhang, Zachary Ende, Martin J. Deymier, Terry Lee, Joel Singer, Tony Mazzulli, Eric Hunter, Mario A. Ostrowski
Pathogenesis and Immunity
Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity
Miyu Moriyama, Manabu Igarashi, Takumi Koshiba, Takashi Irie, Ayato Takada, Takeshi Ichinohe
Pathogenesis and Immunity
Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection
Binghao J. Peng, Jonathan M. Carlson, Michael K. P. Liu, Feng Gao, Nilu Goonetilleke, Andrew J. McMichael, Persephone Borrow, Jill Gilmour, Sonya L. Heath, Eric Hunter, Anju Bansal, Paul A. Goepfert
Pathogenesis and Immunity
Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection
Doty B. A. Ojwach, Daniel MacMillan, Tarylee Reddy, Vladimir Novitsky, Zabrina L. Brumme, Mark A. Brockman, Thumbi Ndung'u, Jaclyn K. Mann
Pathogenesis and Immunity
Sera from Individuals with Narrowly Focused Influenza Virus Antibodies Rapidly Select Viral Escape Mutations In Ovo
Amy K. F. Davis, Kevin McCormick, Megan E. Gumina, Joshua G. Petrie, Emily T. Martin, Katherine S. Xue, Jesse D. Bloom, Arnold S. Monto, Frederic D. Bushman, Scott E. Hensley
Pathogenesis and Immunity
Phosphatase Cdc25A Negatively Regulates the Antiviral Immune Response by Inhibiting TBK1 Activity
Dandan Qi, Lei Hu, Tong Jiao, Tinghong Zhang, Xiaomei Tong, Xin Ye
Open Access

Pathogenesis and Immunity | Spotlight
Testicular Degeneration and Infertility following Arbovirus Infection
Giantonella Puggioni, Davide Pintus, Eleonora Melzi, Giorgio Meloni, Angela Maria Rocchigiani, Caterina Maestrale, Daniela Manunta, Giovanni Savini, Maria Dattena, Annalisa Oggiano, Massimo Palmarini, Ciriaco Ligios
Pathogenesis and Immunity
Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Renders B Cells Hyperresponsive to Secondary Infections
Sang-Hoon Sin, Anthony B. Eason, Rachele Bigi, Yongbaek Kim, SunAh Kang, Kelly Tan, Tischan A. Seltzer, Raman Venkataramanan, Hyowon An, Dirk P. Dittmer