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Cover Figure


Cover photograph (Copyright © 2009, American Society for Microbiology. All Rights Reserved.): Quantifying the efficiency of human immunodeficiency virus (HIV) infection resembles the color field painting style of Abstract Expressionism (see Frankenthaler's Bilbao). Each “tile” represents a projection graph of HIV entry efficiency at various CD4 (x axis) and CCR5 (y axis) levels. Red, yellow, and green areas represent high, moderate, and low levels of infectivity at a given CD4/CCR5 expression level. The top and bottom panels represent patterns of HIV infectivity using isolates from elite suppressors and chronic progressors, respectively. The large “tile” is the average from each group; elite suppressor envelopes use CD4 and CCR5 less efficiently than chronic progressor envelopes. Design by Keith Adams. (See related article on p. 11016.)


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