Cover photograph (Copyright © 2008, American Society for Microbiology. All Rights Reserved.): The capsid protein of Potato virus Y (PVY) has the capability to interact with a subset of plant DnaJ-like chaperones from Nicotiana tabacum, designated NtCPIPs. Transgenic tobacco plants ectopically expressing a dominant-interfering variant of NtCPIP2a show reduced cell-to-cell movement of green fluorescent protein-labeled PVY (green color; lower left image) from microprojectile-bombarded epidermal cells (red color) and, consequently, strongly increased resistance to PVY infection (lower right image) in comparison to the wild-type control (upper images). (See related article in November 2007: vol. 81, issue 21, page 11870.)