Cover photograph (Copyright © 2008, American Society for Microbiology. All Rights Reserved.): Three-dimensional (3-D) reconstruction of a coxsackievirus B3 complexed with the complement regulatory protein, decay-accelerating factor (DAF), which the virus uses as a cellular receptor. Interaction with the virus alters the structure of DAF from the known crystal structure. The density in the 3-D reconstruction that corresponds to DAF is gold, and the virus density is shaded blue according to radius, in order to show the location of the canyon in darker blue. The altered structure of DAF is repeated in the background in gold as a wire trace of the carbon alpha backbone. (See related article in December 2007: vol. 81, issue 23, page 12927.)