Cover photograph (Copyright © 2007, American Society for Microbiology. All Rights Reserved.): Live covisualization of competing adeno-associated virus (AAV) and herpes simplex virus type 1 (HSV-1) DNA replication. Replicating AAV DNA containing lac operator sequences was visualized by binding of a red fluorescent protein fused to lac repressor protein (red), while the replication of HSV-1 DNA containing tetracycline operator sequences was visualized by binding of enhanced yellow fluorescent protein fused to the tetracycline repressor DNA binding domain (green). AAV and HSV-1 DNA replication occurred in spatially separate nuclear compartments, which were often found in juxtaposition. Blue, Hoechst stain; scale in micrometers. (See related article on page 4732.)
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