Cover photograph (Copyright © 2007, American Society for Microbiology. All Rights Reserved.): Electron micrograph of adeno-associated virus (AAV) type 2 fivefold mutant particles shown together with a three-dimensional (3D) reconstruction of the parvovirus capsid in which the fivefold pores are colored blue. Structure function studies with AAV capsid proteins are providing direct evidence of the role of this capsid motif in the virus life cycle. Illustration by Jack Griffith (University of North Carolina School of Medicine); electron microscopy, 3D parvovirus reconstruction, and Adobe artwork provided by Ivana Semova (University of North Carolina School of Medicine), Mavis Agbandje-McKenna (University of Florida), and Noel Hawke and Abbhineet Uppal (University of North Carolina School of Medicine). (See related articles on page 7833 and in September 2006: vol. 80, issue 18, page 8961, and November 2006: vol. 80, issue 22, page 11393.)
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