Cover photograph (Copyright © 2007, American Society for Microbiology. All Rights Reserved.): Tipranavir is a nonpeptide human immunodeficiency virus type 1 (HIV-1) protease inhibitor capable of maintaining high affinity in the face of several HIV-1 protease mutations commonly associated with resistance to other drugs. The structure of the tipranavir-HIV-1 protease complex, shown poised above a diffraction image, is based on the coordinates of crystallographic model 204P. Protease is shown in red, and tipranavir is in yellow. (See related article in May 2007: vol. 81, no. 10, page 5144.)
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