Cover photograph (Copyright © 2007, American Society for Microbiology. All Rights Reserved.): The transmission history of foot-and-mouth disease virus (FMDV) can be elucidated from complete genome sequence analysis of the virus, enabling epidemiological tracing of the virus between infected premises. The United Kingdom map shows the location of premises infected during the 2001 FMDV outbreak. The structure is a representation of FMDV British field strain (serotype O), showing the alpha-carbon backbone (accession IFOD), courtesy of Nick Knowles, Institute for Animal Health, Pirbright, United Kingdom. (See related article in November 2006: vol. 80, issue 22, p. 11274.)