Cover photograph (Copyright © 2006, American Society for Microbiology. All Rights Reserved.): Cos-7 cells were transfected with a plasmid coding for the rotavirus spike protein VP4 fused to enhanced green fluorescent protein (EGFP). At 48 h posttransfection, EGFP-VP4 (green), F-actin (red), and microtubules (blue) were visualized. The EGFP-VP4 protein colocalized with the actin in large bodies (pseudocolored yellow), suggesting that EGFP-VP4 protein remodeled microfilaments. (See related article on page 3947.)