Cover photograph (Copyright © 2006, American Society for Microbiology. All Rights Reserved.): Accumulation of simian virus 40 (SV40) virions at the nuclear envelope at a late stage during viral replication. Shortly after nuclear envelope localization of VP1, the host nuclear, endoplasmic reticulum, and plasma membranes become permeabilized, facilitating the release of viral progeny. BS-C-1 cells were infected with SV40, fixed at 72 h postinfection, and immunostained for the viral capsid protein VP1. This image shows a rotated three-dimensional reconstruction of the central portion of a VP1-stained nucleus. (See related article in July 2006: vol. 80, issue 13, page 6575.)