Cover photograph (Copyright © 2006, American Society for Microbiology. All Rights Reserved.): Factors that influence activation to productive replication act separately on the two gammaherpesviruses, Epstein-Barr-related virus of rhesus monkeys (rhEBV) and rhesus monkey rhadinovirus (RRV), even within the same B lymphocyte. Fluorescent in situ hybridization reveals rhEBV genomes in red and RRV genomes in green. Fine, punctate nuclear staining likely represents individual genomes in latent infection. Diffuse, intense staining is indicative of productive replicative infection. Nuclei are revealed in blue by DAPI (4`,6`-diamidino-2-phenylindole) staining. (See related article in April 2006: vol. 80, no. 7, page 3644.))