Cover photograph (Copyright © 2005, American Society for Microbiology. All Rights Reserved.): Plant viruses actively translocate within and between the cells by using the host transport machineries. The image shows the association of the Beet yellows virus-encoded homolog of the Hsp70 molecular chaperones (green) with the actin microfilaments (red). The fluorophore-tagged Hsp70 and microfilament marker talin were transiently coexpressed in plant cells, and the image was obtained using a confocal laser-scanning microscope and the computer program Visart (Zeiss, Jena, Germany). Evidence suggests that viral proteins and possibly particles hijack the actomyosin motility system to reach the cell periphery and move to adjacent cells. (See related article on page 14421.)