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Spotlight:

Articles of Significant Interest Selected from This Issue by the Editors
J. Virol. 2005 79: 12615-12616. [Full Text] [PDF] FREE  

Structure and Assembly:

Takashi Irie and Ronald N. Harty

L-Domain Flanking Sequences Are Important for Host Interactions and Efficient Budding of Vesicular Stomatitis Virus Recombinants
J. Virol. 2005 79: 12617-12622. [Abstract] [Full Text] [PDF]  

Wolfgang Peti, Margaret A. Johnson, Torsten Herrmann, Benjamin W. Neuman, Michael J. Buchmeier, Mike Nelson, Jeremiah Joseph, Rebecca Page, Raymond C. Stevens, Peter Kuhn, and Kurt Wüthrich

Structural Genomics of the Severe Acute Respiratory Syndrome Coronavirus: Nuclear Magnetic Resonance Structure of the Protein nsP7
J. Virol. 2005 79: 12905-12913. [Abstract] [Full Text] [PDF]  

Tian-Cheng Li, Naokazu Takeda, Tatsuo Miyamura, Yoshiharu Matsuura, Joseph C. Y. Wang, Helena Engvall, Lena Hammar, Li Xing, and R. Holland Cheng

Essential Elements of the Capsid Protein for Self-Assembly into Empty Virus-Like Particles of Hepatitis E Virus
J. Virol. 2005 79: 12999-13006. [Abstract] [Full Text] [PDF]  

Masaya Takemoto, Masato Koike, Yasuko Mori, Sayoko Yonemoto, Yumi Sasamoto, Kazuhiro Kondo, Yasuo Uchiyama, and Koichi Yamanishi

Human Herpesvirus 6 Open Reading Frame U14 Protein and Cellular p53 Interact with Each Other and Are Contained in the Virion
J. Virol. 2005 79: 13037-13046. [Abstract] [Full Text] [PDF]  

Wali Hafezi, Emmanuelle Bernard, Rachelle Cook, and Gillian Elliott

Herpes Simplex Virus Tegument Protein VP22 Contains an Internal VP16 Interaction Domain and a C-Terminal Domain That Are Both Required for VP22 Assembly into the Virus Particle
J. Virol. 2005 79: 13082-13093. [Abstract] [Full Text] [PDF]  

Vincent H. J. Leonard, Alain Kohl, Jane C. Osborne, Angela McLees, and Richard M. Elliott

Homotypic Interaction of Bunyamwera Virus Nucleocapsid Protein
J. Virol. 2005 79: 13166-13172. [Abstract] [Full Text] [PDF]  

Genetic Diversity and Evolution:

Chen-Fu Yang, Hour-Young Chen, Jaume Jorba, Hui-Chih Sun, Su-Ju Yang, Hsiang-Chi Lee, Yhu-Chering Huang, Tzou-Yien Lin, Pei-Jer Chen, Hiroyuki Shimizu, Yorihiro Nishimura, Andi Utama, Mark Pallansch, Tatsuo Miyamura, Olen Kew, and Jyh-Yuan Yang

Intratypic Recombination among Lineages of Type 1 Vaccine-Derived Poliovirus Emerging during Chronic Infection of an Immunodeficient Patient
J. Virol. 2005 79: 12623-12634. [Abstract] [Full Text] [PDF]  

K. Ebner, W. Pinsker, and T. Lion

Comparative Sequence Analysis of the Hexon Gene in the Entire Spectrum of Human Adenovirus Serotypes: Phylogenetic, Taxonomic, and Clinical Implications
J. Virol. 2005 79: 12635-12642. [Abstract] [Full Text] [PDF]  

Minetaro Arita, Shuang-Li Zhu, Hiromu Yoshida, Tetsuo Yoneyama, Tatsuo Miyamura, and Hiroyuki Shimizu

A Sabin 3-Derived Poliovirus Recombinant Contained a Sequence Homologous with Indigenous Human Enterovirus Species C in the Viral Polymerase Coding Region
J. Virol. 2005 79: 12650-12657. [Abstract] [Full Text] [PDF] [Supplemental material]  

Andrew J. Davison and Nigel D. Stow

New Genes from Old: Redeployment of dUTPase by Herpesviruses
J. Virol. 2005 79: 12880-12892. [Abstract] [Full Text] [PDF]  

Paul Cantalupo, Adrienne Doering, Christopher S. Sullivan, Achintya Pal, K. W. C. Peden, Andrew M. Lewis, and James M. Pipas

Complete Nucleotide Sequence of Polyomavirus SA12
J. Virol. 2005 79: 13094-13104. [Abstract] [Full Text] [PDF]  

Virus-Cell Interactions:

Kelly Ann Meulendyke, Mark Allen Wurth, Richard O. McCann, and Rebecca Ellis Dutch

Endocytosis Plays a Critical Role in Proteolytic Processing of the Hendra Virus Fusion Protein
J. Virol. 2005 79: 12643-12649. [Abstract] [Full Text] [PDF]  

Shaomin Tian, Won-Tak Choi, Dongxiang Liu, James Pesavento, Youli Wang, Jing An, Joseph G. Sodroski, and Ziwei Huang

Distinct Functional Sites for Human Immunodeficiency Virus Type 1 and Stromal Cell-Derived Factor 1 on CXCR4 Transmembrane Helical Domains
J. Virol. 2005 79: 12667-12673. [Abstract] [Full Text] [PDF]  

Kathryn S. Jones, Cari Petrow-Sadowski, Daniel C. Bertolette, Ying Huang, and Francis W. Ruscetti

Heparan Sulfate Proteoglycans Mediate Attachment and Entry of Human T-Cell Leukemia Virus Type 1 Virions into CD4⁺ T Cells
J. Virol. 2005 79: 12692-12702. [Abstract] [Full Text] [PDF]  

Cara Theresia Pager and Rebecca Ellis Dutch

Cathepsin L Is Involved in Proteolytic Processing of the Hendra Virus Fusion Protein
J. Virol. 2005 79: 12714-12720. [Abstract] [Full Text] [PDF]  

Martha Simpson-Holley, Robert C. Colgrove, Grzegorz Nalepa, J. Wade Harper, and David M. Knipe

Identification and Functional Evaluation of Cellular and Viral Factors Involved in the Alteration of Nuclear Architecture during Herpes Simplex Virus 1 Infection
J. Virol. 2005 79: 12840-12851. [Abstract] [Full Text] [PDF]  

Jaewook Oh and Steven S. Broyles

Host Cell Nuclear Proteins Are Recruited to Cytoplasmic Vaccinia Virus Replication Complexes
J. Virol. 2005 79: 12852-12860. [Abstract] [Full Text] [PDF]  

Elizabeth Rieder, Tina Henry, Hernando Duque, and Barry Baxt

Analysis of a Foot-and-Mouth Disease Virus Type A₂₄ Isolate Containing an SGD Receptor Recognition Site In Vitro and Its Pathogenesis in Cattle
J. Virol. 2005 79: 12989-12998. [Abstract] [Full Text] [PDF]  

Xuesong Cao, Peng Zhou, Xiaoming Zhang, Shifeng Zhu, Xuehua Zhong, Qi Xiao, Biao Ding, and Yi Li

Identification of an RNA Silencing Suppressor from a Plant Double-Stranded RNA Virus
J. Virol. 2005 79: 13018-13027. [Abstract] [Full Text] [PDF]  

Helene Leuzinger, Urs Ziegler, Elisabeth M. Schraner, Cornel Fraefel, Daniel L. Glauser, Irma Heid, Mathias Ackermann, Martin Mueller, and Peter Wild

Herpes Simplex Virus 1 Envelopment Follows Two Diverse Pathways
J. Virol. 2005 79: 13047-13059. [Abstract] [Full Text] [PDF]  

Christina L. Stallings and Saul Silverstein

Dissection of a Novel Nuclear Localization Signal in Open Reading Frame 29 of Varicella-Zoster Virus
J. Virol. 2005 79: 13070-13081. [Abstract] [Full Text] [PDF]  

Vaibhav Tiwari, Christian Clement, Perry M. Scanlan, Devanand Kowlessur, Beatrice Y. J. T. Yue, and Deepak Shukla

A Role for Herpesvirus Entry Mediator as the Receptor for Herpes Simplex Virus 1 Entry into Primary Human Trabecular Meshwork Cells
J. Virol. 2005 79: 13173-13179. [Abstract] [Full Text] [PDF]  

Fang Lu, Latasha Day, and Paul M. Lieberman

Kaposi's Sarcoma-Associated Herpesvirus Virion-Induced Transcription Activation of the ORF50 Immediate-Early Promoter
J. Virol. 2005 79: 13180-13185. [Abstract] [Full Text] [PDF]  

Cellular Response to Infection:

Jennifer P. Wang, Evelyn A. Kurt-Jones, Ok S. Shin, Michael D. Manchak, Myron J. Levin, and Robert W. Finberg

Varicella-Zoster Virus Activates Inflammatory Cytokines in Human Monocytes and Macrophages via Toll-Like Receptor 2
J. Virol. 2005 79: 12658-12666. [Abstract] [Full Text] [PDF]  

Chi L. Ong, Janine C. Thorpe, Paul R. Gorry, Sylvie Bannwarth, Anthony Jaworowski, Jane L. Howard, Sean Chung, Shahan Campbell, Helen S. Christensen, Guerline Clerzius, Andrew J. Mouland, Anne Gatignol, and Damian F. J. Purcell

Low TRBP Levels Support an Innate Human Immunodeficiency Virus Type 1 Resistance in Astrocytes by Enhancing the PKR Antiviral Response
J. Virol. 2005 79: 12763-12772. [Abstract] [Full Text] [PDF]  

Christophe Préhaud, Françoise Mégret, Mireille Lafage, and Monique Lafon

Virus Infection Switches TLR-3-Positive Human Neurons To Become Strong Producers of Beta Interferon
J. Virol. 2005 79: 12893-12904. [Abstract] [Full Text] [PDF]  

Jean Dahl, John You, and Thomas L. Benjamin

Induction and Utilization of an ATM Signaling Pathway by Polyomavirus
J. Virol. 2005 79: 13007-13017. [Abstract] [Full Text] [PDF]  

Pathogenesis and Immunity:

Gabriela Bleiber, Margaret May, Raquel Martinez, Pascal Meylan, Jürg Ott, Jacques S. Beckmann, Amalio Telenti the Swiss HIV Cohort Study

Use of a Combined Ex Vivo/In Vivo Population Approach for Screening of Human Genes Involved in the Human Immunodeficiency Virus Type 1 Life Cycle for Variants Influencing Disease Progression
J. Virol. 2005 79: 12674-12680. [Abstract] [Full Text] [PDF] [Supplemental material]  

Mark H. Fogg, Amitinder Kaur, Young-Gyu Cho, and Fred Wang

The CD8⁺ T-Cell Response to an Epstein-Barr Virus-Related Gammaherpesvirus Infecting Rhesus Macaques Provides Evidence for Immune Evasion by the EBNA-1 Homologue
J. Virol. 2005 79: 12681-12691. [Abstract] [Full Text] [PDF]  

Anne E. Tebo, Michael J. Fuller, Dalia E. Gaddis, Kyoko Kojima, Kunal Rehani, and Allan J. Zajac

Rapid Recruitment of Virus-Specific CD8 T Cells Restructures Immunodominance during Protective Secondary Responses
J. Virol. 2005 79: 12703-12713. [Abstract] [Full Text] [PDF]  

Alexa Raney, Lillian S. Kuo, Laura L. Baugh, John L. Foster, and J. Victor Garcia

Reconstitution and Molecular Analysis of an Active Human Immunodeficiency Virus Type 1 Nef/p21-Activated Kinase 2 Complex
J. Virol. 2005 79: 12732-12741. [Abstract] [Full Text] [PDF]  

Masanori Matsui, Osamu Moriya, Takayuki Yoshimoto, and Toshitaka Akatsuka

T-bet Is Required for Protection against Vaccinia Virus Infection
J. Virol. 2005 79: 12798-12806. [Abstract] [Full Text] [PDF]  

Sonja M. Best, Keely L. Morris, Jeffrey G. Shannon, Shelly J. Robertson, Dana N. Mitzel, Gregory S. Park, Elena Boer, James B. Wolfinbarger, and Marshall E. Bloom

Inhibition of Interferon-Stimulated JAK-STAT Signaling by a Tick-Borne Flavivirus and Identification of NS5 as an Interferon Antagonist
J. Virol. 2005 79: 12828-12839. [Abstract] [Full Text] [PDF]  

Anne Schaap, Jean-Francois Fortin, Marvin Sommer, Leigh Zerboni, Shaye Stamatis, Chia-Chi Ku, Garry P. Nolan, and Ann M. Arvin

T-Cell Tropism and the Role of ORF66 Protein in Pathogenesis of Varicella-Zoster Virus Infection
J. Virol. 2005 79: 12921-12933. [Abstract] [Full Text] [PDF]  

Jesper Melchjorsen, Søren B. Jensen, Lene Malmgaard, Simon B. Rasmussen, Friedemann Weber, Andrew G. Bowie, Sampsa Matikainen, and Søren R. Paludan

Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner
J. Virol. 2005 79: 12944-12951. [Abstract] [Full Text] [PDF]  

Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld

De Novo Generation of Escape Variant-Specific CD8⁺ T-Cell Responses following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection
J. Virol. 2005 79: 12952-12960. [Abstract] [Full Text] [PDF]  

Georg M. Lauer, Michaela Lucas, Joerg Timm, Kei Ouchi, Arthur Y. Kim, Cheryl L. Day, Julian Schulze zur Wiesch, Glaucia Paranhos-Baccala, Isabelle Sheridan, Deborah R. Casson, Markus Reiser, Rajesh T. Gandhi, Bin Li, Todd M. Allen, Raymond T. Chung, Paul Klenerman, and Bruce D. Walker

Full-Breadth Analysis of CD8⁺ T-Cell Responses in Acute Hepatitis C Virus Infection and Early Therapy
J. Virol. 2005 79: 12979-12988. [Abstract] [Full Text] [PDF]  

Royce A. Wilkinson, Chayne Piscitelli, Martin Teintze, Lisa A. Cavacini, Marshall R. Posner, and C. Martin Lawrence

Structure of the Fab Fragment of F105, a Broadly Reactive Anti-Human Immunodeficiency Virus (HIV) Antibody That Recognizes the CD4 Binding Site of HIV Type 1 gp120
J. Virol. 2005 79: 13060-13069. [Abstract] [Full Text] [PDF]  

James E. Cummins, Jr., Roumiana S. Boneva, William M. Switzer, Logan L. Christensen, Paul Sandstrom, Walid Heneine, Louisa E. Chapman, and Charlene S. Dezzutti

Mucosal and Systemic Antibody Responses in Humans Infected with Simian Foamy Virus
J. Virol. 2005 79: 13186-13189. [Abstract] [Full Text] [PDF]  

Genome Replication and Regulation of Viral Gene Expression:

Ákos Putics, Witold Filipowicz, Jonathan Hall, Alexander E. Gorbalenya, and John Ziebuhr

ADP-Ribose-1"-Monophosphatase: a Conserved Coronavirus Enzyme That Is Dispensable for Viral Replication in Tissue Culture
J. Virol. 2005 79: 12721-12731. [Abstract] [Full Text] [PDF]  

John W. Balliet, Jonathan C. Min, Mark S. Cabatingan, and Priscilla A. Schaffer

Site-Directed Mutagenesis of Large DNA Palindromes: Construction and In Vitro Characterization of Herpes Simplex Virus Type 1 Mutants Containing Point Mutations That Eliminate the oriL or oriS Initiation Function
J. Virol. 2005 79: 12783-12797. [Abstract] [Full Text] [PDF]  

Anice C. Lowen and Richard M. Elliott

Mutational Analyses of the Nonconserved Sequences in the Bunyamwera Orthobunyavirus S Segment Untranslated Regions
J. Virol. 2005 79: 12861-12870. [Abstract] [Full Text] [PDF]  

Ender Simsek, Anand Mehta, Tianlun Zhou, Raymond A. Dwek, and Timothy Block

Hepatitis B Virus Large and Middle Glycoproteins Are Degraded by a Proteasome Pathway in Glucosidase-Inhibited Cells but Not in Cells with Functional Glucosidase Enzyme
J. Virol. 2005 79: 12914-12920. [Abstract] [Full Text] [PDF]  

Sonia Delgado, Ángel E. Martínez de Alba, Carmen Hernández, and Ricardo Flores

A Short Double-Stranded RNA Motif of Peach Latent Mosaic Viroid Contains the Initiation and the Self-Cleavage Sites of Both Polarity Strands
J. Virol. 2005 79: 12934-12943. [Abstract] [Full Text] [PDF]  

Amy N. Loveland, Chee-Kai Chan, Edward J. Brignole, and Wade Gibson

Cleavage of Human Cytomegalovirus Protease pUL80a at Internal and Cryptic Sites Is Not Essential but Enhances Infectivity
J. Virol. 2005 79: 12961-12968. [Abstract] [Full Text] [PDF]  

James W. Bruce, Kenneth A. Bradley, Paul Ahlquist, and John A. T. Young

Isolation of Cell Lines That Show Novel, Murine Leukemia Virus-Specific Blocks to Early Steps of Retroviral Replication
J. Virol. 2005 79: 12969-12978. [Abstract] [Full Text] [PDF]  

Robert Yung-Liang Wang, Chia-Ning Shen, Min-Hui Lin, David Tosh, and Chiaho Shih

Hepatocyte-Like Cells Transdifferentiated from a Pancreatic Origin Can Support Replication of Hepatitis B Virus
J. Virol. 2005 79: 13116-13128. [Abstract] [Full Text] [PDF]  

Zoltán Zádori, József Szelei, and Peter Tijssen

SAT: a Late NS Protein of Porcine Parvovirus
J. Virol. 2005 79: 13129-13138. [Abstract] [Full Text] [PDF]  

Tomomi Nakahara, Woei Ling Peh, John Doorbar, Denis Lee, and Paul F. Lambert

Human Papillomavirus Type 16 E1E4 Contributes to Multiple Facets of the Papillomavirus Life Cycle
J. Virol. 2005 79: 13150-13165. [Abstract] [Full Text] [PDF]  

Gene Delivery:

Cornelis A. M. de Haan, Bert Jan Haijema, David Boss, Frank W. H. Heuts, and Peter J. M. Rottier

Coronaviruses as Vectors: Stability of Foreign Gene Expression
J. Virol. 2005 79: 12742-12751. [Abstract] [Full Text] [PDF]  

Patrick L. Sinn, Erin R. Burnight, Melissa A. Hickey, Gary W. Blissard, and Paul B. McCray, Jr.

Persistent Gene Expression in Mouse Nasal Epithelia following Feline Immunodeficiency Virus-Based Vector Gene Transfer
J. Virol. 2005 79: 12818-12827. [Abstract] [Full Text] [PDF]  

Lucas Chan, Darren Nesbeth, Taylor MacKey, Joanna Galea-Lauri, Joop Gäken, Francisco Martin, Mary Collins, Ghulam Mufti, Farzin Farzaneh, and David Darling

Conjugation of Lentivirus to Paramagnetic Particles via Nonviral Proteins Allows Efficient Concentration and Infection of Primary Acute Myeloid Leukemia Cells
J. Virol. 2005 79: 13190-13194. [Abstract] [Full Text] [PDF]  

Transformation and Oncogenesis:

Kazuo Nishigaki, Charlotte Hanson, Delores Thompson, Takashi Yugawa, and Sandra Ruscetti

Activation of the Jun N-Terminal Kinase Pathway by Friend Spleen Focus-Forming Virus and Its Role in the Growth and Survival of Friend Virus-Induced Erythroleukemia Cells
J. Virol. 2005 79: 12752-12762. [Abstract] [Full Text] [PDF]  

Vaccines and Antiviral Agents:

Johan Vingerhoets, Hilde Azijn, Els Fransen, Inky De Baere, Liesbet Smeulders, Dirk Jochmans, Koen Andries, Rudi Pauwels, and Marie-Pierre de Béthune

TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments
J. Virol. 2005 79: 12773-12782. [Abstract] [Full Text] [PDF]  

Andrés Báez-Astúa, Elsa Herráez-Hernández, Natalio Garbi, Hilda A. Pasolli, Victoria Juárez, Harald zur Hausen, and Angel Cid-Arregui

Low-Dose Adenovirus Vaccine Encoding Chimeric Hepatitis B Virus Surface Antigen-Human Papillomavirus Type 16 E7 Proteins Induces Enhanced E7-Specific Antibody and Cytotoxic T-Cell Responses
J. Virol. 2005 79: 12807-12817. [Abstract] [Full Text] [PDF]  

Yasushi Ami, Yasuyuki Izumi, Kazuhiro Matsuo, Kenji Someya, Masaru Kanekiyo, Shigeo Horibata, Naoto Yoshino, Koji Sakai, Katsuaki Shinohara, Sohkichi Matsumoto, Takeshi Yamada, Shudo Yamazaki, Naoki Yamamoto, and Mitsuo Honda

Priming-Boosting Vaccination with Recombinant Mycobacterium bovis Bacillus Calmette-Guérin and a Nonreplicating Vaccinia Virus Recombinant Leads to Long-Lasting and Effective Immunity
J. Virol. 2005 79: 12871-12879. [Abstract] [Full Text] [PDF]  

Omar Haffar, Larisa Dubrovsky, Richard Lowe, Reem Berro, Fatah Kashanchi, Jeffrey Godden, Christophe Vanpouille, Jürgen Bajorath, and Michael Bukrinsky

Oxadiazols: a New Class of Rationally Designed Anti-Human Immunodeficiency Virus Compounds Targeting the Nuclear Localization Signal of the Viral Matrix Protein
J. Virol. 2005 79: 13028-13036. [Abstract] [Full Text] [PDF]  

Michel Liuzzi, Stephen W. Mason, Mireille Cartier, Carol Lawetz, Robert S. McCollum, Nathalie Dansereau, Gordon Bolger, Nicole Lapeyre, Yvon Gaudette, Lisette Lagacé, Marie-Josée Massariol, Florence Dô, Paul Whitehead, Lyne Lamarre, Erika Scouten, Josée Bordeleau, Serge Landry, Jean Rancourt, Gulrez Fazal, and Bruno Simoneau

Inhibitors of Respiratory Syncytial Virus Replication Target Cotranscriptional mRNA Guanylylation by Viral RNA-Dependent RNA Polymerase
J. Virol. 2005 79: 13105-13115. [Abstract] [Full Text] [PDF]  

Guang Yang, Daniel C. Pevear, Marc H. Davies, Marc S. Collett, Tom Bailey, Susan Rippen, Linda Barone, Chris Burns, Gerry Rhodes, Sanjeev Tohan, John W. Huggins, Robert O. Baker, R. L. Mark Buller, Erin Touchette, Kem Waller, Jill Schriewer, Johan Neyts, Erik DeClercq, Kevin Jones, Dennis Hruby, and Robert Jordan

An Orally Bioavailable Antipoxvirus Compound (ST-246) Inhibits Extracellular Virus Formation and Protects Mice from Lethal Orthopoxvirus Challenge
J. Virol. 2005 79: 13139-13149. [Abstract] [Full Text] [PDF]  

Errata:

Veronique Stove, Inge Van de Walle, Evelien Naessens, Elisabeth Coene, Christophe Stove, Jean Plum, and Bruno Verhasselt

Human Immunodeficiency Virus Nef Induces Rapid Internalization of the T-Cell Coreceptor CD8ß
J. Virol. 2005 79: 13195. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.