Cover photograph (Copyright © 2005, American Society for Microbiology. All Rights Reserved.): Noncytopathic bovine viral diarrhea virus (ncpBVDV) induces IFN-α from a minor population of cells in the absence of detectable productive infection. A section of lymph node harvested 3 days after ncpBVDV infection is shown; nuclei are stained blue, BVDV nonstructural protein NS3, green, and IFN-α, red. The induction of IFN-α production in vivo is in contrast to the failure of ncpBVDV to induce IFN-α from a wide range of cell types in vitro. (See related article on page 7738.)