Cover photograph (Copyright © 2005, American Society for Microbiology. All Rights Reserved.): Silencing the expression of the rotavirus nonstructural ER-resident glycoprotein NSP4 (red) by RNA interference causes a redistribution of the structural protein VP6 (green) from its usual localization in viroplasms (left cell) to fibers along the cell cytoplasm (right cells). Nuclei are stained blue. (See related article on page 184.)