Cover photograph (Copyright © 2004, American Society for Microbiology. All Rights Reserved.): Cabbage leaf curl virus requires two proteins, a nuclear shuttle protein (NSP) and a cell-to-cell movement protein (MP), to move its single-strand DNA genome from nuclear sites of replication to the cytoplasm. In this image, shown against a background of the viral plant host Arabidopsis thaliana, a GFP-NSP fusion protein (green) accumulates in nuclei when expressed alone in plant protoplasts (middle and lower right) and relocalizes to the cortical endoplasmic reticulum when coexpressed with MP (top). The red signal shows the distribution of chloroplasts in these confocal three-dimensional reconstructions. (See related article on page 11161.)