Cover photograph (Copyright © 2004, American Society for Microbiology. All Rights Reserved.): Replication of the RNA genome and assembly of the inner core of rotavirus occur in viral inclusion bodies that form in the cytoplasm of infected cells. At the periphery of the inclusions, assembly of VP6 (green) around the cores produces double-layered particles. These particles interact with the outer shell glycoprotein VP7 (red), embedded in the endoplasmic reticulum that surrounds the inclusions. The illustration also depicts punctate sites (yellow) where budding of the particles into the lumen of the endoplasmic reticulum presumably occurs, yielding triple-layered virions. The nucleus is stained blue. (See related article in July 2004: vol. 78, issue 14, p. 7763.)