Cover photograph (Copyright © 2003, American Society for Microbiology. All Rights Reserved.): A fusion between HMGA1a and the DNA-binding domain of EBNA1 coats metaphase chromosomes. Metaphase spreads were retrieved from colcemid-blocked 293 cells expressing a chimeric protein consisting of the DNA-binding domain of Epstein-Barr virus nuclear antigen 1 fused to the high mobility group protein HMGA1a. Deconvolved images captured after indirect immunofluorescence against EBNA1 revealed a punctate localization to metaphase chromosomes counterstained with DAPI. This staining profile is strikingly similar to that displayed by wild-type EBNA1. (See related article on page 11767.)