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Cover photograph (Copyright © 2003, American Society for Microbiology. All Rights Reserved.): Venezuelan equine encephalomyelitis virus (VEEV), a mosquito-borne arbovirus, is a leading cause of viral encephalitis in humans and horses in the Americas. The structure of the nucleocapsid isolated from VEEV has been determined by electron cryomicroscopy and image reconstruction. This structure provides the first three-dimensional image of a nucleocapsid isolated from a single-stranded, enveloped RNA virus and shows that a simple enveloped virus undergoes large conformational changes during maturation. (Art by Joy Goodgame and Angel Paredes.) (See related article in January 2003: vol. 77, issue 1, p. 659.)
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