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Cover photograph (Copyright © 2003, American Society for Microbiology. All Rights Reserved.): Spindle transformation of primary human umbilical vein endothelial cells by Kaposi's sarcoma-associated herpesvirus (KSHV). Primary human umbilical vein endothelial cells were infected with an infectious KSHV derived from a recombinant bacterial artificial chromosome. Infected cells express green fluorescent protein from a cassette in the recombinant viral genome and are converted to spindle shapes, forming bundle structures that are reminiscent of Kaposi's sarcoma vascular structures. (See related article on page 9738.)
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