Cover photograph (Copyright © 2003, American Society for Microbiology. All Rights Reserved.): Human rhinovirus 3, a picornavirus that causes the common cold in humans, infects cells by first attaching to intercellular adhesion molecule 1 on the cell surface. Binding of the receptor leads to conformational changes in the viral capsid, resulting in viral genome release. Comparative structural analysis of three virus uncoating intermediates by cryo-electron microscopy reveals that the receptor molecule serves as a mediator, seizing the "breathing" capsid in an open expanded state so that the viral genome can exit from the cage. (See related article on p. 6101.)