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Contents: October 2002, Volume 76, Issue 20        Pathogenesis and Immunity        Virus-Cell Interactions        Structure and Assembly        Vaccines and Antiviral Agents        Replication        Gene Therapy        Recombination and Evolution        Transformation and Oncogenesis        Letters to the Editor

Table of Contents

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Pathogenesis and Immunity:

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Characterization of an Enteropathogenic Bovine Calicivirus Representing a Potentially New Calicivirus Genus J. R. Smiley, K. O. Chang, J. Hayes, J. Vinjé, and L. J. Saif J. Virol. October 2002 76: 10089-10098; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quantitation of Human Immunodeficiency Virus Type 1 DNA Forms with the Second Template Switch in Peripheral Blood Cells Predicts Disease Progression Independently of Plasma RNA Load Leondios G. Kostrikis, Giota Touloumi, Rose Karanicolas, Nikos Pantazis, Cleo Anastassopoulou, Anastasia Karafoulidou, James J. Goedert, and Angelos Hatzakis J. Virol. October 2002 76: 10099-10108; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Magnitude and Frequency of Cytotoxic T-Lymphocyte Responses: Identification of Immunodominant Regions of Human Immunodeficiency Virus Type 1 Subtype C V. Novitsky, H. Cao, N. Rybak, P. Gilbert, M. F. McLane, S. Gaolekwe, T. Peter, I. Thior, T. Ndung'u, R. Marlink, T. H. Lee, and M. Essex J. Virol. October 2002 76: 10155-10168; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates during Structured Intermittent Antiretroviral Therapy Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, and Huldrych F. Günthard J. Virol. October 2002 76: 10169-10176; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High Levels of Viral Replication Contrast with Only Transient Changes in CD4+ and CD8+ Cell Numbers during the Early Phase of Experimental Infection with Simian Immunodeficiency Virus SIVmnd-1 in Mandrillus sphinx Richard Onanga, Christopher Kornfeld, Ivona Pandrea, Jerome Estaquier, Sandrine Souquière, Pierre Rouquet, Virginie Poaty Mavoungou, Olivier Bourry, Souleymane M'Boup, Françoise Barré-Sinoussi, François Simon, Cristian Apetrei, Pierre Roques, and Michaela C. Müller-Trutwin J. Virol. October 2002 76: 10256-10263; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mice Deficient in Perforin, CD4+ T Cells, or CD28-Mediated Signaling Maintain the Typical Immunodominance Hierarchies of CD8+ T-Cell Responses to Influenza Virus Weisan Chen, Jack R. Bennink, Phillip A. Morton, and Jonathan W. Yewdell J. Virol. October 2002 76: 10332-10337; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phenotypic and Functional Alterations of Dendritic Cells Induced by Human Herpesvirus 6 Infection Miki Kakimoto, Atsuhiko Hasegawa, Shigeru Fujita, and Masaki Yasukawa J. Virol. October 2002 76: 10338-10345; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Exchange of the C-Terminal Part of VP3 from Very Virulent Infectious Bursal Disease Virus Results in an Attenuated Virus with a Unique Antigenic Structure Hein J. Boot, A. Agnes H. M. ter Huurne, Arjan J. W. Hoekman, Jan M. Pol, Arno L. J. Gielkens, and Ben P. H. Peeters J. Virol. October 2002 76: 10346-10355; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

BCL-2 and BAX Protect Adult Mice from Lethal Sindbis Virus Infection but Do Not Protect Spinal Cord Motor Neurons or Prevent Paralysis Douglas A. Kerr, Thomas Larsen, Susan H. Cook, Yih-Ru Fannjiang, Eunkyung Choi, Diane E. Griffin, J. Marie Hardwick, and David N. Irani J. Virol. October 2002 76: 10393-10400; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Life Cycle Heterogeneity in Animal Models of Human Papillomavirus-Associated Disease Woei Ling Peh, Kate Middleton, Neil Christensen, Philip Nicholls, Kiyofumi Egawa, Karl Sotlar, Janet Brandsma, Alan Percival, Jon Lewis, Wen Jun Liu, and John Doorbar J. Virol. October 2002 76: 10401-10416; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Elevated Chemokine Responses Are Maintained in Lungs after Clearance of Viral Infection Jason B. Weinberg, Mary L. Lutzke, Stacey Efstathiou, Steven L. Kunkel, and Rosemary Rochford J. Virol. October 2002 76: 10518-10523; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Replication by a Two-Amino-Acid Insertion in HIV-1 Vif from a Nonprogressing Mother and Child Louis Alexander, Mary Janette Aquino-DeJesus, Michael Chan, and Warren A. Andiman J. Virol. October 2002 76: 10533-10539; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification and Expression of Immunogenic Proteins of a Disease-Associated Marine Turtle Herpesvirus Sadie S. Coberley, Richard C. Condit, Lawrence H. Herbst, and Paul A. Klein J. Virol. October 2002 76: 10553-10558; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Virus-Cell Interactions:

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Naturally Occurring Substitutions in the P/V Gene Convert the Noncytopathic Paramyxovirus Simian Virus 5 into a Virus That Induces Alpha/Beta Interferon Synthesis and Cell Death Elizabeth K. Wansley and Griffith D. Parks J. Virol. October 2002 76: 10109-10121; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Adaptation of Alphaviruses to Heparan Sulfate: Interaction of Sindbis and Semliki Forest Viruses with Liposomes Containing Lipid-Conjugated Heparin Jolanda M. Smit, Barry-Lee Waarts, Koji Kimata, William B. Klimstra, Robert Bittman, and Jan Wilschut J. Virol. October 2002 76: 10128-10137; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Vesicular Stomatitis Virus Infection Alters the eIF4F Translation Initiation Complex and Causes Dephosphorylation of the eIF4E Binding Protein 4E-BP1 John H. Connor and Douglas S. Lyles J. Virol. October 2002 76: 10177-10187; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Study of Antigen-Processing Steps Reveals Preferences Explaining Differential Biological Outcomes of Two HLA-A2-Restricted Immunodominant Epitopes from Human Immunodeficiency Virus Type 1 W. M. Cohen, A. Bianco, F. Connan, L. Camoin, M. Dalod, G. Lauvau, E. Ferriès, B. Culmann-Penciolelli, P. M. van Endert, J. P. Briand, J. Choppin, and J. G. Guillet J. Virol. October 2002 76: 10219-10225; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Promoter Sequences Required for Reactivation of Epstein-Barr Virus from Latency Ulrich K. Binné, Wolfgang Amon, and Paul J. Farrell J. Virol. October 2002 76: 10282-10289; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Signal Transduction and Transcription Factor Modification during Reactivation of Epstein-Barr Virus from Latency Helen Bryant and Paul J. Farrell J. Virol. October 2002 76: 10290-10298; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Addition of a Single gp120 Glycan Confers Increased Binding to Dendritic Cell-Specific ICAM-3-Grabbing Nonintegrin and Neutralization Escape to Human Immunodeficiency Virus Type 1 James Lue, Mayla Hsu, David Yang, Preston Marx, Zhiwei Chen, and Cecilia Cheng-Mayer J. Virol. October 2002 76: 10299-10306; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The NS2 Proteins of Parvovirus Minute Virus of Mice Are Required for Efficient Nuclear Egress of Progeny Virions in Mouse Cells Virginie Eichwald, Laurent Daeffler, Michèle Klein, Jean Rommelaere, and Nathalie Salomé J. Virol. October 2002 76: 10307-10319; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role for Human Immunodeficiency Virus Type 1 Membrane Cholesterol in Viral Internalization Mireille Guyader, Etsuko Kiyokawa, Laurence Abrami, Priscilla Turelli, and Didier Trono J. Virol. October 2002 76: 10356-10364; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sequential Localization of Two Herpes Simplex Virus Tegument Proteins to Punctate Nuclear Dots Adjacent to ICP0 Domains Ian Hutchinson, Alison Whiteley, Helena Browne, and Gillian Elliott J. Virol. October 2002 76: 10365-10373; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selective Translation of Eukaryotic mRNAs: Functional Molecular Analysis of GRSF-1, a Positive Regulator of Influenza Virus Protein Synthesis John C. Kash, Dawn M. Cunningham, Maria W. Smit, Youngwoo Park, David Fritz, Jeffrey Wilusz, and Michael G. Katze J. Virol. October 2002 76: 10417-10426; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Epstein-Barr Virus-Induced Changes in B-Lymphocyte Gene Expression Kara L. Carter, Ellen Cahir-McFarland, and Elliott Kieff J. Virol. October 2002 76: 10427-10436; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Influenza Virus Can Enter and Infect Cells in the Absence of Clathrin-Mediated Endocytosis Sara B. Sieczkarski and Gary R. Whittaker J. Virol. October 2002 76: 10455-10464; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mitochondrial Targeting and Membrane Anchoring of a Viral Replicase in Plant and Yeast Cells Frédérique Weber-Lotfi, André Dietrich, Marcello Russo, and Luisa Rubino J. Virol. October 2002 76: 10485-10496; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Zebrafish Coxsackievirus and Adenovirus Receptor Homologue Interacts with Coxsackie B Virus and Adenovirus JenniElizabeth Petrella, Christopher J. Cohen, Jedidiah Gaetz, and Jeffrey M. Bergelson J. Virol. October 2002 76: 10503-10506; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Specificity and Affinity of Sialic Acid Binding by the Rhesus Rotavirus VP8* Core Philip R. Dormitzer, Zhen-Yu J. Sun, Ola Blixt, James C. Paulson, Gerhard Wagner, and Stephen C. Harrison J. Virol. October 2002 76: 10512-10517; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Structure and Assembly:

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Nonspecific Nucleoside Triphosphatase P4 of Double-Stranded RNA Bacteriophage 6 Is Required for Single-Stranded RNA Packaging and Transcription Markus J. Pirttimaa, Anja O. Paatero, Mikko J. Frilander, and Dennis H. Bamford J. Virol. October 2002 76: 10122-10127; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Genetic Evidence that the Hydrophobic Anchors of Glycoproteins E2 and E1 Interact during Assembly of Alphaviruses Ellen G. Strauss, Edith M. Lenches, and James H. Strauss J. Virol. October 2002 76: 10188-10194; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A P22 Scaffold Protein Mutation Increases the Robustness of Head Assembly in the Presence of Excess Portal Protein Sean D. Moore and Peter E. Prevelige, Jr. J. Virol. October 2002 76: 10245-10255; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Structural Model of Pestivirus Erns Based on Disulfide Bond Connectivity and Homology Modeling Reveals an Extremely Rare Vicinal Disulfide J. P. M. Langedijk, P. A. van Veelen, W. M. M. Schaaper, A. H. de Ru, R. H. Meloen, and M. M. Hulst J. Virol. October 2002 76: 10383-10392; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Vaccines and Antiviral Agents:

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Newcastle Disease Virus (NDV) Marker Vaccine: an Immunodominant Epitope on the Nucleoprotein Gene of NDV Can Be Deleted or Replaced by a Foreign Epitope Teshome Mebatsion, Marck J. M. Koolen, Leonie T. C. de Vaan, Niels de Haas, Marian Braber, Angela Römer-Oberdörfer, Paul van den Elzen, and Pieter van der Marel J. Virol. October 2002 76: 10138-10146; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Slowly Declining Levels of Viral RNA and DNA in DNA/Recombinant Modified Vaccinia Virus Ankara-Vaccinated Macaques with Controlled Simian-Human Immunodeficiency Virus SHIV-89.6P Challenges Yuyang Tang, Francois Villinger, Silvija I. Staprans, Rama Rao Amara, James M. Smith, James G. Herndon, and Harriet L. Robinson J. Virol. October 2002 76: 10147-10154; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Gamma Interferon-Dependent Protection of the Mouse Upper Respiratory Tract following Parenteral Immunization with a Respiratory Syncytial Virus G Protein Fragment Helene Plotnicky-Gilquin, Dominique Cyblat-Chanal, Jean-Pierre Aubry, Thierry Champion, Alain Beck, Thien Nguyen, Jean-Yves Bonnefoy, and Nathalie Corvaïa J. Virol. October 2002 76: 10203-10210; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mimovirus: a Novel Form of Vaccine That Induces Hepatitis B Virus-Specific Cytotoxic T-Lymphocyte Responses In Vivo Yu-Zhang Wu, Jian-Ping Zhao, Ying Wan, Zheng-Cai Jia, Wei Zhou, Jiang Bian, Bing Ni, Li-Yun Zou, and Yan Tang J. Virol. October 2002 76: 10264-10269; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Prenylation Inhibitor Prevents Production of Infectious Hepatitis Delta Virus Particles Bruno B. Bordier, Patricia L. Marion, Kazuo Ohashi, Mark A. Kay, Harry B. Greenberg, John L. Casey, and Jeffrey S. Glenn J. Virol. October 2002 76: 10465-10472; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection Todd M. Allen, Peicheng Jing, Briana Calore, Helen Horton, David H. O'Connor, Tomas Hanke, Marian Piekarczyk, Richard Ruddersdorf, Bianca R. Mothé, Carol Emerson, Nancy Wilson, Jeffrey D. Lifson, Igor M. Belyakov, Jay A. Berzofsky, Chenxi Wang, David B. Allison, David C. Montefiori, Ronald C. Desrosiers, Steven Wolinsky, Kevin J. Kunstman, John D. Altman, Alessandro Sette, Andrew J. McMichael, and David I. Watkins J. Virol. October 2002 76: 10507-10511; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Protective Antiviral Immune Responses to Pseudorabies Virus Induced by DNA Vaccination Using Dimethyldioctadecylammonium Bromide as an Adjuvant Eugene M. A. van Rooij, Harrie L. Glansbeek, Luuk A. T. Hilgers, Eddie G. te Lintelo, Yolanda E. de Visser, Wim J. A. Boersma, Bart L. Haagmans, and Andre T. J. Bianchi J. Virol. October 2002 76: 10540-10545; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Insertions in the Reverse Transcriptase Increase both Drug Resistance and Viral Fitness in a Human Immunodeficiency Virus Type 1 Isolate Harboring the Multi-Nucleoside Reverse Transcriptase Inhibitor Resistance 69 Insertion Complex Mutation Miguel E. Quiñones-Mateu, Mahlet Tadele, Mariona Parera, Antonio Mas, Jan Weber, Héctor R. Rangel, Bikram Chakraborty, Bonaventura Clotet, Esteban Domingo, Luis Menéndez-Arias, and Miguel A. Martínez J. Virol. October 2002 76: 10546-10552; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Replication:

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A Secondary Structure That Contains the 5' and 3' Splice Sites Suppresses Splicing of Duck Hepatitis B Virus Pregenomic RNA Daniel D. Loeb, Amanda A. Mack, and Ru Tian J. Virol. October 2002 76: 10195-10202; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

RU5 of Mason-Pfizer Monkey Virus 5' Long Terminal Repeat Enhances Cytoplasmic Expression of Human Immunodeficiency Virus Type 1 gag-pol and Nonviral Reporter RNA Stacey Hull and Kathleen Boris-Lawrie J. Virol. October 2002 76: 10211-10218; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Replacement of the P1 Amino Acid of Human Immunodeficiency Virus Type 1 Gag Processing Sites Can Inhibit or Enhance the Rate of Cleavage by the Viral Protease Steve C. Pettit, Gavin J. Henderson, Celia A. Schiffer, and Ronald Swanstrom J. Virol. October 2002 76: 10226-10233; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of the Putative Replisome Organizer of the Lactococcal Bacteriophage r1t Manuel Zúñiga, Blandine Franke-Fayard, Gerard Venema, Jan Kok, and Arjen Nauta J. Virol. October 2002 76: 10234-10244; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evidence against a Simple Tethering Model for Enhancement of Herpes Simplex Virus DNA Polymerase Processivity by Accessory Protein UL42 Murari Chaudhuri and Deborah S. Parris J. Virol. October 2002 76: 10270-10281; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Functional Dissection of Latency-Associated Nuclear Antigen 1 of Kaposi's Sarcoma-Associated Herpesvirus Involved in Latent DNA Replication and Transcription of Terminal Repeats of the Viral Genome Chunghun Lim, Hekwang Sohn, Daeyoup Lee, Yousang Gwack, and Joonho Choe J. Virol. October 2002 76: 10320-10331; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human T-Cell Lymphotropic Virus Type 1 p12I Expression Increases Cytoplasmic Calcium To Enhance the Activation of Nuclear Factor of Activated T Cells Wei Ding, Björn Albrecht, Robert E. Kelley, Natarajan Muthusamy, Seung-Jae Kim, Ruth A. Altschuld, and Michael D. Lairmore J. Virol. October 2002 76: 10374-10382; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Immunodeficiency Virus Type 1 Nucleocapsid Protein Nuclear Localization Mediates Early Viral mRNA Expression Jielin Zhang and Clyde S. Crumpacker J. Virol. October 2002 76: 10444-10454; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rev Inhibition Strongly Affects Intracellular Distribution of Human Immunodeficiency Virus Type 1 RNAs Dusan Cmarko, Stig-Ove Bøe, Catia Scassellati, Anne Marie Szilvay, Svend Davanger, Xiang-Dong Fu, Gunnar Haukenes, Karl-Henning Kalland, and Stanislav Fakan J. Virol. October 2002 76: 10473-10484; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Herpesvirus 8 Gene Encodes a Functional Thymidylate Synthase Gábor Gáspár, Erik De Clercq, and Johan Neyts J. Virol. October 2002 76: 10530-10532; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phosphorylation of the Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein Sarah K. Wootton, Raymond R. R. Rowland, and Dongwan Yoo J. Virol. October 2002 76: 10569-10576; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Gene Therapy:

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Bronchoalveolar Fluid Is Not a Major Hindrance to Virus-Mediated Gene Therapy in Cystic Fibrosis C. P. Rooney, G. M. Denning, B. P. Davis, D. M. Flaherty, J. A. Chiorini, and J. Zabner J. Virol. October 2002 76: 10437-10443; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Improved Hepatic Gene Transfer by Using an Adeno-Associated Virus Serotype 5 Vector Federico Mingozzi, Jörg Schüttrumpf, Valder R. Arruda, Yuhong Liu, Yi-Lin Liu, Katherine A. High, Weidong Xiao, and Roland W. Herzog J. Virol. October 2002 76: 10497-10502; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Recombination and Evolution:

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Evolutionary Dynamics of Viral Attenuation Marty R. Badgett, Alexandra Auer, Leland E. Carmichael, Colin R. Parrish, and James J. Bull J. Virol. October 2002 76: 10524-10529; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Transformation and Oncogenesis:

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Inactivation of both the Retinoblastoma Tumor Suppressor and p21 by the Human Papillomavirus Type 16 E7 Oncoprotein Is Necessary To Inhibit Cell Cycle Arrest in Human Epithelial Cells Anna-Marija Helt, Jens Oliver Funk, and Denise A. Galloway J. Virol. October 2002 76: 10559-10568; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters to the Editor:

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Synergy Determination Issues Ting-Chao Chou, Arthur Nádas, and Susan Zolla-Pazner J. Virol. October 2002 76: 10577-10578; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.