Cover photograph (Copyright © 2001, American Society for Microbiology. All rights reserved.): Distribution of endogenous zyxin in a human melanoma cell line transfected with E6 proteins. Cells were transfected with a DNA construct expressing the E6 protein of human papillomavirus type 11 (HPV-11). The distribution of zyxin and E6 in the cells was detected by confocal microscopy. The HPV-11 E6-myc protein is nuclear (green), and there is no detectable zyxin (red) in the nucleus of these cells. When the same experiment is done with HPV-6 E6, some of the endogenous zyxin is found to colocalize with the signal from the nucleus-located HPV-6 E6-myc. Thus, HPV-6 E6 can mobilize a cell adhesion protein to the nucleus. (See related article in December 2001: vol. 75, no. 23, p. 11791.)