Cover photograph (Copyright © 2001, American Society for Microbiology. All rights reserved.): Recombinant coxsackievirus type B3 causes severe pancreatitis. A C57BL/6 mouse was infected intraperitoneally with 10⁶ PFU of the recombinant coxsackievirus rCVB3.2, and 9 days later the pancreas was examined histologically after trichrome staining. A massive mononuclear cell infiltrate was seen, along with destruction of much of the exocrine pancreas; only occasional acinar cells survived (the zymogen granules of which are stained a deep burgundy). Consistent with the known pancreatic tropism of coxsackievirus, the islets of Langerhans (lower right of photograph) were spared. (See related article in the March 2001 issue: vol. 75, no. 5, p. 2377-2387.)