Cover photograph (Copyright © 2000, American Society for Microbiology. All rights reserved.): Immunodominant epitopes of hepatitis E virus (HEV) are conformational and poorly revealed in the full-length capsid protein, PORF2. HepG2 cells expressing full-length PORF2 after transient transfection show strong reactivity with monoclonal antibodies against linear epitopes by indirect immunofluorescence staining (green) but weak reactivity with monoclonal antibodies to the immunodominant, conformational epitopes found in HEV virus-like particles. Cell nuclei were counterstained with propidium iodide (red). Magnification, ×200. (See related article in September 2000, issue 17: vol. 74, page 8011.)