Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere
- aDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
- bDepartments of Medicine, Molecular Microbiology, Pathology, and Immunology and The Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, Missouri, USA
- T. C. Pierson, Editor
ABSTRACT
Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications brought this virus into the spotlight as causing an infection of global public health concern. In this review, we discuss the history and epidemiology of ZIKV infection, recent outbreaks in Oceania and the emergence of ZIKV in the Western Hemisphere, newly ascribed complications of ZIKV infection, including Guillain-Barré syndrome and microcephaly, potential interactions between ZIKV and dengue virus, and the prospects for the development of antiviral agents and vaccines.
FOOTNOTES
- Accepted manuscript posted online 9 March 2016.
- Address correspondence to Helen M. Lazear, helen.lazear{at}med.unc.edu, or Michael S. Diamond, diamond{at}borcim.wustl.edu.
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Citation Lazear HM, Diamond MS. 2016. Zika virus: new clinical syndromes and its emergence in the Western Hemisphere. J Virol 90:4864–4875. doi:10.1128/JVI.00252-16.
- Copyright © 2016, American Society for Microbiology. All Rights Reserved.
