Coordinated Neutralization and Immune Activation by the Cytosolic Antibody Receptor TRIM21
- B. Tsai, Editor
ABSTRACT
TRIM21 is a high-affinity antibody receptor uniquely expressed in the cytosol of mammalian cells. Here we summarize its role in extending antibody protection into the intracellular environment and allowing nonprofessional cells to benefit from adaptive immunity. We highlight recent work that has shed light on how TRIM21 acts as both an immune sensor and effector. We also review how TRIM21 synergizes with other innate immune receptors to promote an integrated antiviral response.
FOOTNOTES
- Accepted manuscript posted online 2 March 2016.
- Address correspondence to Leo C. James, lcj{at}mrc-lmb.cam.ac.uk.
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Citation Fletcher AJ, James LC. 2016. Coordinated neutralization and immune activation by the cytosolic antibody receptor TRIM21. J Virol 90:4856–4859. doi:10.1128/JVI.00050-16.
- Copyright © 2016, American Society for Microbiology. All Rights Reserved.
