Surface Glycoproteins of an African Henipavirus Induce Syncytium Formation in a Cell Line Derived from an African Fruit Bat, Hypsignathus monstrosus

  1. Georg Herrlera
  1. Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germanya
  2. Institute of Virology, Philipps University Marburg, Marburg, Germanyb
  3. Institute of Virology, University of Bonn Medical Centrer, Bonn, Germanyc

ABSTRACT

Serological screening and detection of genomic RNA indicates that members of the genus Henipavirus are present not only in Southeast Asia but also in African fruit bats. We demonstrate that the surface glycoproteins F and G of an African henipavirus (M74) induce syncytium formation in a kidney cell line derived from an African fruit bat, Hypsignathus monstrosus. Despite a less broad cell tropism, the M74 glycoproteins show functional similarities to glycoproteins of Nipah virus.

FOOTNOTES

    • Received 27 August 2013.
    • Accepted 17 September 2013.
  • Address correspondence to Georg Herrler, georg.herrler{at}tiho-hannover.de.

  • Published ahead of print 25 September 2013

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  1. Accepted manuscript posted online 25 September 2013, doi: 10.1128/JVI.02458-13 J. Virol. vol. 87 no. 24 13889-13891
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