Viral Dynamics during Primary Simian Immunodeficiency Virus Infection: Effect of Time-Dependent Virus Infectivity▿

1. 

   View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   FIG. 1.

   Time-dependent infection rate β.
2. 

   View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   FIG. 2.

   Fitted viral dynamics curves using the two models (solid line, model with time-varying infectivity; dashed line, model with constant infectivity) to the observed viral load data (•) for the eight donor animals in reference 26. Note how the fits with the varying infectivity model are systematically better, especially during the early part of viral growth, when the infectivity is varying faster.
3. 

   View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   FIG. 3.

   Viral dynamics model curves using estimated parameters (solid line, model with time-varying infectivity; dashed line, model with constant infectivity) and observed viral load data (•) for three ramp-up plasma recipient animals (a) and three set-point plasma recipient animals in reference 26 (b).
4. 

   View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   FIG. 4.

   Average time-varying infection rate β(t) for donor animals (red), ramp-up plasma recipient animals (blue), set-point plasma recipient animals (green), and overall animals (black). Horizontal dashed lines represent the constant infection rate estimated by using model with constant infectivity.

• American Society for Microbiology