Estimation of the Initial Viral Growth Rate and Basic Reproductive Number during Acute HIV-1 Infection▿
- Ruy M. Ribeiro1†,
- Li Qin2†,
- Leslie L. Chavez1†,
- Dongfeng Li3,
- Steven G. Self2 and
- Alan S. Perelson1,*
- 1Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico 87545
- 2 Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., LE-400, Seattle, Washington 98109, and Department of Biostatistics, University of Washington, Seattle, Washington 98105
- 3Department of Probability and Statistics, School of Mathematical Sciences, Peking University, Beijing 100871, China
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FIG. 1.Schematic of the calculation of the viral expansion rate, r, and the postpeak decay, α.
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FIG. 2.Profile of the initial viral load (VL) for all patients aligned at the beginning of viral expansion.
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FIG. 3.Early viral load profiles for the 15 patients who showed a viral peak and postpeak decay. The data for these patients were used to estimate the postpeak decay rate of the virus.
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FIG. 4.Histogram of R0 calculated from the highest expansion rate in each of the 47 patients studied.
- American Society for Microbiology
