Estimating the Impact of Vaccination on Acute Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections▿
- Janka Petravic1,
- Ruy M. Ribeiro2,
- Danilo R. Casimiro3,
- Joseph J. Mattapallil4,
- Mario Roederer5,
- John W. Shiver3, and
- Miles P. Davenport1,*
- 1Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales 2052, New South Wales, Australia
- 2Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545
- 3Merck Research Laboratories, West Point, Pennsylvania
- 4Department of Microbiology and Immunology, Uniformed Services University of Health Sciences, Bethesda, Maryland 20824
- 5ImmunoTechnology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
ABSTRACT
The dynamics of HIV infection have been studied in humans and in a variety of animal models. The standard model of infection has been used to estimate the basic reproductive ratio of the virus, calculated from the growth rate of virus in acute infection. This method has not been useful in studying the effects of vaccination, since, for the vaccines developed so far, early growth rates of virus do not differ between control and vaccinated animals. Here, we use the standard model of viral dynamics to derive the reproductive ratio from the peak viral load and nadir of target cell numbers in acute infection. We apply this method to data from studies of vaccination in SHIV and SIV infection and demonstrate that vaccination can reduce the reproductive ratio by 2.3- and 2-fold, respectively. This method allows the comparison of vaccination efficacies among different viral strains and animal models in vivo.
FOOTNOTES
- Received 28 July 2008.
- Accepted 8 September 2008.
- ↵*Corresponding author. Mailing address: Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales 2052, New South Wales, Australia. Phone: 612 9385 2762. Fax: 61-2-9385 1389. E-mail: m.davenport{at}unsw.edu.au
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↵▿ Published ahead of print on 17 September 2008.
- American Society for Microbiology
