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J. Virol. doi:10.1128/JVI.02776-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

EVOLUTIONARY PROCESSES AMONG SYLVATIC DENGUE-2 VIRUSES

Center for Biodefense and Emerging Infectious Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Center for Infectious Disease Dynamics and Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA; Fogarty International Center, National Institutes of Health, Bethesda, MD 20892. USA; Department of Zoology and Botany, University of Buea, Buea, Cameroon; Institute Pasteur de Dakar, Dakar, Senegal

^* To whom correspondence should be addressed. Email: sweaver{at}utmb.edu.

	Abstract

Sylvatic dengue viruses (DENV) are transmitted in an enzootic cycle between non-human primates and arboreal Aedes mosquitoes in Southeast Asia and West Africa. Although previous analyses have revealed the evolutionary processes among endemic (human) DENV, little is known about viral evolution in the sylvatic cycle. Through an analysis of 14 complete coding regions of sylvatic DENV-2 virus sampled over a 33-year period, we show that both the rate of evolutionary change and pattern of natural selection are similar among endemic and sylvatic DENV, although the latter has a uniquely high frequency of positive selection in the NS4B protein gene. Our findings support a recent cross-species transmission event and suggest the possibility of future DENV re-emergence from the sylvatic cycle.

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• Vasilakis, N., Durbin, A. P., da Rosa, A. P. A. T., Munoz-Jordan, J. L., Tesh, R. B., Weaver, S. C. (2008). Antigenic Relationships between Sylvatic and Endemic Dengue Viruses. Am J Trop Med Hyg 79: 128-132 [Abstract] [Full Text]