JVI Accepts, published online ahead of print on 19 March 2008
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J. Virol. doi:10.1128/JVI.02556-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

New genotype of hepatitis B virus identified in Vietnam that showed complex recombinant

Tran Thien Tuan Huy, Trinh Thi Ngoc, and Kenji Abe*

Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan; National Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Hanoi, Vietnam

* To whom correspondence should be addressed. Email: kenjiabe{at}nih.go.jp.


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Abstract

A novel variant of hepatitis B virus was identified in Vietnam. This strain (HBV-VH24) had a novel inter-genotypic recombination between genotypes A, C and G. VH24 showed high similarity (98.3%-98.9%) with the "aberrant strains" among Vietnamese isolates reported by Hannoun et al. in 2000, and also had similar breakpoints of recombination seen among them. Phylogenetic analysis of the complete genome of these strains formed a separate clade. Furthermore, their pre-S/S gene encoded 7 unique conserved amino acid residues were not present in other genotypes. These findings support the designation of a new genotype I.




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