JVI Accepts, published online ahead of print on 23 April 2008
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J. Virol. doi:10.1128/JVI.02550-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Viral specific IL-17 producing CD4+ T cells are detectable in early HIV-1 infection

Feng Yun Yue, Asad Merchant, Colin M. Kovacs, Mona Loutfy, Desmond Persad, and Mario A. Ostrowski*

Clinical Sciences Division, University of Toronto, Toronto, Canada; St. Michael's Hospital, University of Toronto, Toronto, Canada; CIRC (Canadian Immunodeficiency Research Collaborative), Toronto, Canada

* To whom correspondence should be addressed. Email: mario.ostrowski{at}gmail.com.


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Abstract

TH-17 cells have been shown to play a role in bacterial defense, acute inflammation and autoimmunity. We examined the role of IL-17 production in HIV-1 infection. Both HIV-1 and CMV specific IL-17 producing CD4+ T cells were detectable in early HIV-1 infection, but reduced to non-detectable in chronic and non-progressive HIV-1 infection. IL-17 producing CMV specific cells were not detected in blood from HIV-1 uninfected normal volunteers. Viral specific TH-17 cells could co-express other cytokines and could express CCR4 or CXCR3. Although the etiology of these cells is to be established, we propose that microbial translocation may induce them.




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