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J. Virol. doi:10.1128/JVI.02403-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

The ERM family member ezrin regulates stable microtubule formation and retroviral infection

Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY 10032

^* To whom correspondence should be addressed. Email: mojgan.naghavi{at}ucd.ie.

	Abstract

We recently identified the cytoskeletal regulatory protein moesin as a novel gene that inhibits retroviral replication prior to reverse transcription by downregulation of stable microtubule formation. Here, we provide evidence that overexpression of ezrin, another closely related ERM (ezrin-radixin-moesin) family member, also blocks replication of both murine leukemia viruses (MLVs) and human immunodeficiency virus type 1 (HIV-1) in Rat2 fibroblasts before reverse transcription while knockdown of endogenous ezrin increases susceptibility of human cells to HIV-1 infection. Together, these results suggest that ERM proteins may be important determinants of retrovirus susceptibility through negative regulation of stable microtubule networks.