JVI Figure table search 04
Home Help [Feedback] [For Subscribers] [Archive] [Search] --
JVI Accepts, published online ahead of print on 30 August 2006
This Article
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
JVI.01079-06v1
81/2/532    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Madani, N.
Right arrow Articles by Sodroski, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Madani, N.
Right arrow Articles by Sodroski, J.

 Previous Article  |  Next Article 

J. Virol. doi:10.1128/JVI.01079-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Inhibition of Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein-Mediated Single Cell Lysis by Low-Molecular-Weight Antagonists of Viral Entry

Navid Madani, Amy M. Hubicki, Ana Luisa Perdigoto, Martin Springer, and Joseph Sodroski*

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115; Department of Pathology, Division of AIDS, Harvard Medical School, Boston, MA 02115; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115; Department of Biochemical Immunology, Merck & Co., Inc., Rahway, NJ 07065-0900

* To whom correspondence should be addressed. Email: joseph_sodroski{at}dfci.harvard.edu.


  Abstract

The coexpression of human immunodeficiency virus (HIV-1) envelope glycoproteins and receptors leads to the lysis of single cells by a process that is dependent upon membrane fusion. This cell lysis was inhibited by low-molecular-weight compounds that interfere with receptor binding or with receptor-induced conformational transitions in the envelope glycoproteins. A peptide, T20, potently inhibited cell-cell fusion but had no effect on single cell lysis mediated by the HIV-1 envelope glycoproteins. Thus, critical events in the lysis of single cells by the HIV-1 envelope glycoproteins occur in intracellular compartments accessible only to small inhibitory compounds.






Home Help [Feedback] [For Subscribers] [Archive] [Search] --
J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2006 by the American Society for Microbiology. All rights reserved.