JVI Accepts, published online ahead of print on 17 June 2009

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Google Scholar Articles by Reyes-del Valle, J. Articles by Cattaneo, R. PubMed PubMed Citation Articles by Reyes-del Valle, J. Articles by Cattaneo, R.

 Previous Article  |  Next Article 

J. Virol. doi:10.1128/JVI.00906-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Protective anti-hepatitis B responses in Rhesus monkeys primed with a vectored measles virus and boosted with a single hepatitis B surface antigen dose

Jorge Reyes-del Valle, Gregory Hodge, Michael B. McChesney, and Roberto Cattaneo^*

Department of Molecular Medicine and Virology and Gene Therapy Graduate Track, Mayo Clinic College of Medicine, Rochester, MN 55905; California National Primate Research Center and Department of Pathology and Laboratory Medicine, School of Medicine, University of California-Davis, Davis, CA, 95616

^* To whom correspondence should be addressed. Email: Cattaneo.Roberto{at}mayo.edu.

The widely used hepatitis B virus (HBV) vaccine is based on three doses of hepatitis B surface antigen (HBsAg) protein. We previously showed that vectored measles viruses (MV) expressing HBsAg retain measles vaccine function in monkeys, but do not induce a protective anti-HBs response in all animals. We show here that a single HBsAg protein dose following a three dose vaccination regimen with an optimized HBsAg-expressing MV elicits protective anti-HBs responses in all four vaccinated Rhesus monkeys. Vaccination strategies coupling the effective, long-term immunity elicited by the high coverage MV vaccine to prophylactic HBV immunity are discussed.