This Article Full Text (PDF) Other Versions of this Article: JVI.00882-07v1 81/22/12696    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Martínez-Sobrido, L. Articles by de La Torre, J. C. Search for Related Content PubMed PubMed Citation Articles by Martínez-Sobrido, L. Articles by de La Torre, J. C.

 Previous Article  |  Next Article 

J. Virol. doi:10.1128/JVI.00882-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Differential inhibition of type I interferon induction by arenavirus nucleoproteins

Department of Microbiology, Emerging Pathogens Institute, and Microbiology Graduate Training Program, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, and Molecular Integrative Neuroscience Department (MIND), The Scripps Research Institute, La Jolla, California 92037

^* To whom correspondence should be addressed. Email: Juanct{at}scripps.edu.

	Abstract

We have documented that the nucleoprotein (NP) of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is an antagonist of the type I interferon response. In this study we tested the ability of NPs encoded by representative arenavirus species from both Old World (OW) and New World (NW) antigenic groups to inhibit production of interferon. We found that, with the exception of Tacaribe virus (TCRV), all NPs tested inhibited activation of IFN- and IRF3-dependent promoters, as well as the nuclear translocation of IRF-3. Consistent with this observation, TCRV-infected cells also failed to inhibit interferon production.