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J. Virol. doi:10.1128/JVI.00864-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Transcriptome Analysis of NF-B and Phosphatidylinositol 3-Kinase Regulated Genes in Human Cytomegalovirus Infected Monocytes

Department of Microbiology & Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA. 71130-3932; Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA

^* To whom correspondence should be addressed. Email: ayuroc{at}lsuhsc.edu.

	Abstract

Human cytomegalovirus induces a pro-inflammatory monocyte following infection and we have evidence that NF-B and phosphatidylinositol 3-kinase [lsqb]PI(3)K[rsqb] are key mediators in this early activation. To begin to address how these signalling pathways are responsible for the rapid activation of infected monocytes, we examined the role these pathways played in the transcriptome of infected monocytes. Global transcriptional profiling using cDNA microarrays revealed a significant number of genes, including inflammatory genes, were regulated in a NF-B- and/or PI(3)K-dependent manner, identifying these pathways as key cellular control points in the conversion of monocytes to an activated pro-inflammatory state following HCMV infection.

This article has been cited by other articles:

• Chan, G., Bivins-Smith, E. R., Smith, M. S., Smith, P. M., Yurochko, A. D. (2008). Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage. J. Immunol. 181: 698-711 [Abstract] [Full Text]